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NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype
BackgroundSenescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory...
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Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
BackgroundAtherosclerosis, characterized by abnormal arterial lipid deposition, is an age-dependent inflammatory disease and contributes to elevated...
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Cholesterol biosynthetic pathway induces cellular senescence through ERRα
Cellular senescence is a cell program induced by various stresses that leads to a stable proliferation arrest and to a senescence-associated...
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Influence of Altered Gut Microbiota in Cellular Senescence
Senescence is a physiological process a cell undergoes. This process is often considered as a double-edged sword as it as both beneficial and...
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The role of cellular senescence in neurodegenerative diseases
Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer’s disease (AD) and Parkinson’s disease. Different senescent...
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MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1
Senescence, an intricate and inevitable biological process, characterized by the gradual loss of homeostasis and declining organ functions. The...
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The senescence journey in cancer immunoediting
Cancer progression is continuously controlled by the immune system which can identify and destroy nascent tumor cells or inhibit metastatic...
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Role of cellular senescence in inflammation and regeneration
Cellular senescence is the state in which cells undergo irreversible cell cycle arrest and acquire diverse phenotypes. It has been linked to chronic...
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Cellular senescence and neurodegeneration
Advancing age is a major risk factor of Alzheimer’s disease (AD). The worldwide prevalence of AD is approximately 50 million people, and this number...
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Gadd45 in Senescence
Gadd45a, Gadd45b, and Gadd45g have been implicated in cell cycle arrest, DNA repair, apoptosis, innate immunity, genomic stability, and more recently...
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c-Jun N-terminal kinase signaling in cellular senescence
Cellular senescence leads to decreased tissue regeneration and inflammation and is associated with diabetes, neurodegenerative diseases, and...
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Radiation-induced senescence: therapeutic opportunities
The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical...
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DNA damage response(DDR): a link between cellular senescence and human cytomegalovirus
The DNA damage response (DDR) is a signaling cascade that is triggered by DNA damage, involving the halting of cell cycle progression and repair. It...
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ROS-Induced Gingival Fibroblast Senescence: Implications in Exacerbating Inflammatory Responses in Periodontal Disease
Periodontal disease is the pathological outcome of the overwhelming inflammation in periodontal tissue. Cellular senescence has been associated with...
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Cell Death and Replicative Senescence in Cancer
For continuous growth, cancer cells must overcome barriers posed by terminal differentiation, replicative senescence, and cell death by apoptosis....
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RSK3 switches cell fate: from stress-induced senescence to malignant progression
BackgroundTGFβ induces several cell phenotypes including senescence, a stable cell cycle arrest accompanied by a secretory program, and...
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Pharmacological and Nutritional Approaches to Modulate Microglial Polarization in Cognitive Senescence
Brain aging, characterized by age-related changes, significantly impacts cognitive function. Microglia cells are resident macrophages in the CNS that...
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Phosphate and Cellular Senescence
Cellular senescence is one type of permeant arrest of cell growth and one of increasingly recognized contributor to aging and age-associated disease....
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Characteristics of T cell premature senescence in maintenance hemodialysis patients
BackgroundUremia-associated immunodeficiency, mainly characterized by T cell dysfunction, exists in patients on maintenance hemodialysis (MHD) and...
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Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51
BackgroundBleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA...
