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Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study
BackgroundConsiderable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). However, studies remain limited...
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Cerebrospinal fluid amyloid-β and cerebral microbleed are associated with distinct neuropsychiatric sub-syndromes in cognitively impaired patients
BackgroundNeuropsychiatric symptoms (NPS) are prevalent in cognitively impaired individuals including Alzheimer’s disease (AD) dementia and mild...
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Imaging markers of cerebral amyloid angiopathy and hypertensive arteriopathy differentiate Alzheimer disease subtypes synergistically
BackgroundBoth cerebral amyloid angiopathy (CAA) and hypertensive arteriopathy (HA) are related to cognitive impairment and dementia. This study...
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Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities
The major vascular cause of dementia is cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) amongst others. While the...
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Monogenic Causes in Familial Stroke Across Intracerebral Hemorrhage and Ischemic Stroke Subtypes Identified by Whole-Exome Sequencing
Whole exome sequencing (WES) has been used to detect rare causative variants in neurological diseases. However, the efficacy of WES in genetic...
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Test–retest reliability of arterial spin labelling for cerebral blood flow in older adults with small vessel disease
Cerebral small vessel disease (SVD) is common in older people and is associated with lacunar stroke, white matter hyperintensities (WMH) and vascular...
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Explaining the association between social and lifestyle factors and cognitive functions: a pathway analysis in the Memento cohort
BackgroundThis work aimed to investigate the potential pathways involved in the association between social and lifestyle factors, biomarkers of...
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Autoencoders reloaded
In Bourlard and Kamp (Biol Cybern 59(4):291–294, 1998), it was theoretically proven that autoencoders (AE) with single hidden layer (previously...
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A major depressive disorder diagnosis approach based on EEG signals using dictionary learning and functional connectivity features
Major depressive disorder (MDD) as a psychiatric illness negatively affects the behavior and daily life of the patients.Therefore, the early MDD...
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The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration
Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve...
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Selection of the most sensitive configuration of strip array detectors for x-ray beam monitoring in radiotherapy of cancer utilizing singular value decomposition
We propose a concise mathematical framework in order to compare detector configurations efficiently for x-ray beam monitoring in radiotherapy of...
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Optimizing feature subset for schizophrenia detection using multichannel EEG signals and rough set theory
Schizophrenia (SZ) is a mental disorder that causes lifelong disorders based on delusions, cognitive deficits, and hallucinations. By visual...
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Efficacy and Safety of Intravenous rtPA in Ischemic Strokes Due to Small-Vessel Occlusion: Systematic Review and Meta-Analysis
Intravenous recombinant tissue plasminogen activator (iv-rtPA) has been routinely used to treat ischemic stroke for 25 years, following large...
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Biological Equivalence of GGTA-1 Glycosyltransferase Knockout and Standard Porcine Pericardial Tissue Using 90-Day Mitral Valve Implantation in Adolescent Sheep
ObjectiveThere is growing interest in the application of genetically engineered reduced antigenicity animal tissue for manufacture of bioprosthetic...
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Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment
To investigate patterns of hippocampal subfield atrophy among patients with amnestic mild cognitive impairment, stratified by severity of small...
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A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
Cerebral small vessel disease (SVD) is a major health burden, yet the pathophysiology remains poorly understood with no effective treatment. Since...
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Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury
In cerebral small vessel disease (cSVD), whole brain MRI markers of cSVD-related brain injury explain limited variance to support individualized...
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Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates
Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close...
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Identification of Parkinson’s Disease from Speech Using CNNs and Formant Measures
Parkinson’s Disease (PD) is a neurodegenerative disorder that severely impacts the motor capabilities of patients. Dysarthria is one of the symptoms...
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Classification of pure conduct disorder from healthy controls based on indices of brain networks during resting state
Conduct disorder (CD) is an important mental health problem in childhood and adolescence. There is presently a trend of revealing neural mechanisms...
