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The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis
BackgroundRhabdomyosarcoma (RMS) is a rare malignancy and the most common soft tissue sarcoma in children. Vasculogenic mimicry (VM) is a novel tumor...
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SNAI2/FTH1P3/miR-218-5p Positive Feedback Loop Promotes Colorectal Cancer Metastasis
Colorectal cancer (CRC) is a type of intestinal cancer that causes more than 600,000 deaths every year. Overcoming the problems of metastasis...
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TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavum
BackgroundHypertrophy of ligamentum flavum (HLF) is the mainly cause of lumbar spinal stenosis (LSS), but the precise mechanism of HLF formation has...
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EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway
BackgroundThe prognosis of pancreatic cancer patients remains relatively poor. Although some patients would receive surgical resection, distant...
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LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex
BackgroundThe biological function of lncRNA ELF3-AS1 remains largely unknown in cancers. The cause of SNAI2 overexpression in tumor metastasis...
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Bile acids increase intestinal marker expression via the FXR/SNAI2/miR-1 axis in the stomach
PurposeIntestinal metaplasia (IM) is a precancerous lesion that increases the risk of subsequent gastric cancer (GC) development. Previously, miR-1...
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SP1-Driven FOXM1 Upregulation Induces Dopaminergic Neuron Injury in Parkinson’s Disease
The aberrant expression of Forkhead box M1 (FOXM1) has been associated with the pathological processes of Parkinson’s disease (PD), but the upstream...
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Identification of upstream miRNAs of SNAI2 and their influence on the metastasis of gastrointestinal stromal tumors
BackgroundSNAI2, a member of the snail zinc finger protein family, plays an important role in the metastasis of several types of carcinoma.
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Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose
BackgroundPeritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis.
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DRP1 inhibition-mediated mitochondrial elongation abolishes cancer stemness, enhances glutaminolysis, and drives ferroptosis in oral squamous cell carcinoma
BackgroundMitochondrial dynamics play a fundamental role in determining stem cell fate. However, the underlying mechanisms of mitochondrial dynamics...
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Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice
BackgroundKrüppel-like factor 10 (KLF10) is involved in a positive feedback loop that regulates transforming growth factor β (TGFβ) signaling, and...
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Potential of miR-181a-5p and miR-630 as clinical biomarkers in NSCLC
BackgroundThe development of drug resistance and high mortality rates are the major problems observed in non-small cell lung cancer (NSCLC)....
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Fluid flow exposure promotes epithelial-to-mesenchymal transition and adhesion of breast cancer cells to endothelial cells
BackgroundMechanical interactions between tumor cells and microenvironments are frequent phenomena during breast cancer progression, however, it is...
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CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug
BackgroundRecent studies have identified that circular RNAs (circRNAs) have an important role in cancer via their well-recognized sponge effect on...
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MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition
BackgroundLymph node and distant metastasis contribute to poor outcomes in patients with oral squamous cell carcinoma (OSCC). The mechanisms...
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Estrogen receptor-α-miR-1271-SNAI2 feedback loop regulates transforming growth factor-β-induced breast cancer progression
BackgroundBreast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and...
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ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK
BackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors globally. Understanding the molecular basis of...
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TMPRSS4 promotes cancer stem–like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1
BackgroundTransmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored serine protease. Elevated expression of TMPRSS4 correlates with poor...
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Targeting Epithelial-to-Mesenchymal Transition for Breast Cancer Stem Cells Therapeutics
Metastasis of breast cancer cells involves the dissemination from primary tumor sites and migration to distant organs forming secondary tumors, which...
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Targeting Epithelial-to-Mesenchymal Transition for Breast Cancer Stem Cells Therapeutics
Metastasis of breast cancer cells involves the dissemination from primary tumor sites and migration to distant organs forming secondary tumors, which...
