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nArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders
Despite the complex genetic architecture, a broad spectrum of psychiatric disorders can still be caused by mutation(s) in the same gene. These...
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The Shank/ProSAP N-Terminal (SPN) Domain of Shank3 Regulates Targeting to Postsynaptic Sites and Postsynaptic Signaling
Members of the Shank family of postsynaptic scaffold proteins (Shank1–3) link neurotransmitter receptors to the actin cytoskeleton in dendritic...
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Molecular Dynamic Simulation of Neurexin1α Mutations Associated with Mental Disorder
Neurexin1 gene is essential for formulating synaptic cell adhesion to establish synapses. In a previous work, 38 SNPs in Neurexin1 recoded in mental...
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Post-translational modifications in liquid-liquid phase separation: a comprehensive review
Liquid-liquid phase separation (LLPS) has received significant attention in recent biological studies. It refers to a phenomenon that biomolecule...
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Genetics of OCD and Related Disorders; Searching for Shared Factors
Obsessive compulsive disorder (OCD) and several other obsessive-compulsive related disorders (OCRDs) including hoarding disorder, body dysmorphic...
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Physiological and pathological effects of phase separation in the central nervous system
Phase separation, also known as biomolecule condensate, participates in physiological processes such as transcriptional regulation, signal...
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Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats
Compulsivity is a core symptom in different psychopathological disorders, characterized by excessive behaviors and behavioral inflexibility. The...
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Biomolecular condensate assembly of nArgBP2 tunes its functionality to manifest the structural plasticity of dendritic spines
nArgBP2, a candidate gene for intellectual disability, is a postsynaptic protein critical for dendritic spine development and morphogenesis, and its...
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Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors
Autism spectrum disorder (ASD) is a complex heterogeneous consortium of pervasive development disorders (PDD) which ranges from atypical autism,...
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Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice
Autism Spectrum Disorders (ASD) are characterised by deficits in social interactions and repetitive behaviours. Multiple ASD-associated mutations...
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Pharmacotherapeutic Strategies and New Targets in OCD
Effective pharmacological and psychotherapeutic treatments are well established for obsessive-compulsive disorder (OCD). Serotonin reuptake...
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The Postsynaptic Density
The postsynaptic density is a dense, submembranous filamentous structure beneath the postsynaptic membrane. It is a disklike structure that may or...
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The sympathetic nervous system in development and disease
The sympathetic nervous system prepares the body for ‘fight or flight’ responses and maintains homeostasis during daily activities such as exercise,...
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Introduction: What Are Dendritic Spines?
Dendritic spines are cellular specializations that greatly increase the connectivity of neurons and modulate the “weight” of most postsynaptic...
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The Postsynaptic Density
The postsynaptic density is a dense, submembranous filamentous structure beneath the postsynaptic membrane. It is a disklike structure that may or...
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Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients
Synaptic protein shanks (SH3 and multiple ankyrin repeat domains protein, Shank) have emerged as an important mediator of synaptic remodeling....
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Phase separation at the synapse
Emerging evidence indicates that liquid–liquid phase separation, the formation of a condensed molecular assembly within another diluted aqueous...
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SHANK proteins: roles at the synapse and in autism spectrum disorder
Several large-scale genomic studies have supported an association between cases of autism spectrum disorder and mutations in the genes SH3 and...
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The DLGAP family: neuronal expression, function and role in brain disorders
The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the...
