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Renewal of cocaine seeking using social and nonsocial contextual stimuli
RationaleVarious nonsocial cues have been used as stimuli to examine the contextual control of drug seeking behavior, but little is known about the...
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Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium
Regenerative capabilities of the endothelium rely on vessel-resident progenitors termed endothelial colony forming cells (ECFCs). This study aimed to...
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lncRNA SNHG9 enhances liver cancer stem cell self-renewal and tumorigenicity by negatively regulating PTEN expression via recruiting EZH2
Liver cancer stem cell (CSC) self-renewal and tumorigenesis are important causes of hepatocellular carcinoma (HCC) recurrence. We purposed to...
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TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal
Dysregulation of gut homeostasis is associated with irritable bowel syndrome (IBS), a chronic functional gastrointestinal disorder affecting...
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DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer
BackgroundCSLCs(Cancer stem cell-like cells), which are central to tumorigenesis, are intrinsically influenced by epigenetic modifications. This...
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Self-renewal Potential of Cancer Stem Cells
Self-renewal potential is an important characteristic for cancer stem cells (CSCs) to maintain the cancer tissues as well as for the stem cells to...
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Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis
Glioma is a primary brain tumor with limited treatment approaches and glioblastoma stem cells (GSCs) are manifested with the self-renewal capability...
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Gene Therapy for Cardiomyocyte Renewal: Cell Cycle, a Potential Therapeutic Target
Heart disease is the primary cause of death worldwide. Even though extensive research has been done, and many pharmacological and surgical treatments...
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NDRG1 facilitates self-renewal of liver cancer stem cells by preventing EpCAM ubiquitination
BackgroundPortal vein tumour thrombus (PVTT) is the main pathway of HCC intrahepatic metastasis and is responsible for the poor prognosis of patients...
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Telomerase is required for glomerular renewal in kidneys of adult mice
Homeostatic renal filtration relies on the integrity of podocytes, which function in glomerular filtration. These highly specialized cells are...
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Off the Clock: the Non-canonical Roles of Cyclin-Dependent Kinases in Neural and Glioma Stem Cell Self-Renewal
Glioma stem cells (GSCs) are thought to drive growth and therapy resistance in glioblastoma (GBM) by “hijacking” at least a subset of signaling...
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Rapid induction and long-term self-renewal of neural crest-derived ectodermal chondrogenic cells from hPSCs
Articular cartilage is highly specific and has limited capacity for regeneration if damaged. Human pluripotent stem cells (hPSCs) have the potential...
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Wnt/β-catenin signaling stimulates the self-renewal of conjunctival stem cells and promotes corneal conjunctivalization
Limbal stem cell deficiency causes conjunctivalization characterized by the covering of the corneal surface with conjunctival epithelium. However,...
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Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion
BackgroundGlioblastoma patients commonly develop resistance to temozolomide chemotherapy. Hypoxia, which supports chemotherapy resistance, favors the...
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O-GlcNAcylation of Sox2 at threonine 258 regulates the self-renewal and early cell fate of embryonic stem cells
Sox2 is a core transcription factor in embryonic stem cells (ESCs), and O -GlcNAcylation is a type of post-translational modification of...
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Methionine regulates self-renewal, pluripotency, and cell death of GIC through cholesterol—rRNA axis
BackgroundGlioma-initiating cells (GICs) are the source of glioma cells that can self-renew, have pluripotency, and are treatment-resistant, so are...
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YAP regulates porcine skin-derived stem cells self-renewal partly by repressing Wnt/β-catenin signaling pathway
Skin-derived stem cells (SDSCs) are a class of adult stem cells (ASCs) that have the ability to self-renew and differentiate. The regulation...
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HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML
Background:Leukaemia stem cells (LSCs) are responsible for the initiation, maintenance, and recurrence of acute myeloid leukaemia (AML), an...
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Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling
BackgroundHepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity....
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Presynaptic GABAB receptor inhibition sex dependently enhances fear extinction and attenuates fear renewal
Anxiety and trauma-related disorders are highly prevalent worldwide, and are associated with altered associative fear learning. Despite the...
