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Ferritin – a multifaceted protein scaffold for biotherapeutics
The ferritin nanocage is an endogenous protein that exists in almost all mammals. Its hollow spherical structure that naturally stores iron ions has...
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Inhibition of PP2A activity by H2O2 during mitosis disrupts nuclear envelope reassembly and alters nuclear shape
Many types of cancer cells exhibit abnormal nuclear shapes induced by various molecular changes. However, whether reactive oxygen species (ROS)...
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Effects of Ran-GTP/importin β inhibition on the meiotic division of porcine oocytes
The Ran-GTP/importin β pathway has been implicated in a diverse array of mitotic functions in somatic mitosis; however, the possible meiotic roles of...
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Transcriptional dynamics of transposable elements in the type I IFN response in Myotis lucifugus cells
BackgroundBats are a major reservoir of zoonotic viruses, and there has been growing interest in characterizing bat-specific features of innate...
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Label–free Fluorescence Turn on Trypsin Assay Based on Gemini Surfactant/heparin/Nile Red Supramolecular Assembly
In this research, we designed a label-free fluorometric turn-on assay for trypsin and inhibitor screening, based on a spherical cationic gemini...
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A Semiquantitative Protein-Fragment Complementation Assay to Study Protein-Protein Interactions of the Polymerase Complex in Cellula
Protein-fragment complementation assays (PCAs) are powerful tools to investigate protein-protein interactions in a cellular context. These are...
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Structural, angiogenic, and immune responses influencing myocardial regeneration: a glimpse into the crucible
Complete cardiac regeneration remains an elusive therapeutic goal. Although much attention has been focused on cardiomyocyte proliferation,...
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Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the...
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The Multiple Regulatory Roles of Single-Stranded RNA Viral Genomes in Virion Formation and Infection
We describe our discovery, recent findings, and potential implications, of previously unsuspected roles of viral genomes in assembly regulation and...
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Analyses of breakpoint junctions of complex genomic rearrangements comprising multiple consecutive microdeletions by nanopore sequencing
The widespread use of genomic copy number analysis has revealed many previously unknown genomic structural variations, including some which are more...
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Clec7a drives gut fungus-mediated host lipid deposition
BackgroundCompared to that of bacteria, the role of gut fungi in obesity development remains unknown.
ResultsHere, alterations in gut fungal...
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Modulating and monitoring the functionality of corticostriatal circuits using an electrostimulable microfluidic device
The central nervous system is organized into different neural circuits, each with particular functions and properties. Studying neural circuits is...
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Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
BackgroundDuring metastasis, cancer cells undergo epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β), which...
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Characterization of a novel papillomavirus identified from a whale (Delphinapterus leucas) pharyngeal metagenomic library
Here, using viral metagenomic method, a novel whale papillomavirus (temporarily named wPV, GenBank accession number OP856597) was discovered in a...
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Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice
Insufficient revascularization of pancreatic islets is one of the major obstacles impairing the success of islet transplantation. To overcome this...
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Increased Sensitivity of Diagnostic Mutation Detection by Re-analysis Incorporating Local Reassembly of Sequence Reads
BackgroundDiagnostic genetic testing programmes based on next-generation DNA sequencing have resulted in the accrual of large datasets of targeted...
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Corporeal Pedagogy: Visualizing Anatomy Through Art, Archaeology, and Medicine
This chapter outlines the educational methodology, Corporeal Pedagogy established by Dr. Olivia Turner and Dr. Sally Waite, which uses the Shefton...
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Engineering Optogenetic Protein Analogs
This chapter provides an overview of the technologies we have developed to control proteins with light. First, we focus on the LOV domain, a...
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Scientific Thinking: A Mindset for Everyone
It is difficult to instill beginners with experts’ habits of mindMind. Young childrenChildren, for example, frequently lack the content...
