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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules....
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Pyroptosis Signature Gene CHMP4B Regulates Microglia Pyroptosis by Inhibiting GSDMD in Alzheimer’s Disease
In this study, we aimed to work through the key genes involved in the process of pyroptosis in Alzheimer’s disease (AD) to identify potential...
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Live Imaging of Pyroptosis in Primary Murine Macrophages
Inflammasomes are the ultimate weapon of the macrophage immune arsenal. Inflammasome signalling in macrophages triggers pyroptosis, a lytic cell...
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Ferroptosis and Pyroptosis in Epilepsy
Epilepsy is sudden, recurrent, and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain. Ferroptosis and...
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The role of pyroptosis in viral infection
Pyroptosis, also known as inflammatory necrosis, is a form of programmed cell death, which is an important natural immune response. Pyroptosis plays...
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Synergistically Augmenting Cancer Immunotherapy by Physical Manipulation of Pyroptosis Induction
Pyroptosis is a newly recognized type of programmed cell death mediated by the gasdermin family and caspase. It is characterized by the formation of...
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Neuroinflammation Targeting Pyroptosis: Molecular Mechanisms and Therapeutic Perspectives in Stroke
Pyroptosis is a recently identified type of pro-inflammatory programmed cell death (PCD) mediated by inflammasomes and nucleotide oligomerization...
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Molecular probes for monitoring pyroptosis: design, imaging and theranostic application
Pyroptosis is a recently discovered process of programmed cell death that is linked with tumor progression and potential treatment strategies. Unlike...
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Pyroptosis in bone loss
Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has...
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The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies
Pyroptosis is a cell death process characterized by cell swelling until membrane rupture and release of intracellular contents. As an effective tumor...
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The role of pyroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for the majority of all diagnoses and deaths due to liver...
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The Role of Pyroptosis and Autophagy in the Nervous System
Autophagy is a conservative self-degradation system, which includes the two major processes of enveloping abnormal proteins, organelles and other...
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BRD4 promotes gouty arthritis through MDM2-mediated PPARγ degradation and pyroptosis
BackgroundGouty arthritis (GA) is characterized by monosodium urate (MSU) crystal accumulation that instigates NLRP3-mediated pyroptosis; however,...
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PIK3CG Regulates NLRP3/GSDMD-Mediated Pyroptosis in Septic Myocardial Injury
Cardiac insufficiency is a common complication of sepsis with high mortality. Inflammatory programmed cell death (pyroptosis) executed by...
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Live Cell Imaging of T Cell Pyroptosis
Pyroptosis is a lytic, pro-inflammatory cell death program that is tightly regulated by inflammasomes in most cases. Inflammasome-dependent...
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Dihydromyricetin Alleviates Ischemic Brain Injury by Antagonizing Pyroptosis in Rats
Ischemic stroke is a worldwide disease that seriously threatens human health, and there are few effective drugs to treat it. Dihydromyricetin (DHM)...
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Pyroptosis and pyroptosis-inducing cancer drugs
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing...
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Investigating the TLR4/TAK1/IRF7 axis in NLRP3-Mediated Pyroptosis in Parkinson's Disease
In the realm of Parkinson's disease (PD) research, NLRP3 inflammasome-mediated pyroptosis has recently garnered significant attention as a potential...
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Novel Mechanisms of Perioperative Neurocognitive Disorders: Ferroptosis and Pyroptosis
Perioperative neurocognitive disorders (PNDs) are some of the most common postoperative complications among the elderly and susceptible individuals,...
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Maresin1 alleviates liver ischemia/reperfusion injury by reducing liver macrophage pyroptosis
BackgroundCell pyroptosis has a strong proinflammatory effect, but it is unclear whether pyroptosis of liver macrophages exacerbates liver tissue...
