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Gastrodin Regulates PI3K/AKT-Sirt3 Signaling Pathway and Proinflammatory Mediators in Activated Microglia
Activated microglia and their mediated inflammatory responses play an important role in the pathogenesis of hypoxic-ischemic brain damage (HIBD)....
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Inflammation Resolution Mediators: Future Prospects
Inflammation resolution is a complex system that involves a variety of lipid mediators, proteins, hormones, and gaseous mediators that act in a...
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Macrolides and Inflammatory Cells, Signaling, and Mediators
Low-dose long-term macrolide therapy had a remarkable effect on the prognosis of diffuse panbronchiolitis and suppression of airway secretion and...
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Key early proinflammatory signaling molecules encapsulated within circulating exosomes following traumatic injury
BackgroundAssessment of immune status in critically ill patients is often based on serial tracking of systemic cytokine levels and clinical...
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TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2
Periodontitis, characterized by progressive alveolar bone destruction, leads to the loss of attachment and stability of the affected teeth....
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Apolipoprotein D modulates lipid mediators and osteopontin in an anti-inflammatory direction
BackgroundHDL has been proposed to possess anti-inflammatory properties; however, the detail mechanisms have not been fully elucidated.
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Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis
Increasing evidence corroborates the fundamental role of neuroinflammation in the development of epilepsy. Proinflammatory cytokines (PICs) are...
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Effect of Proinflammatory S100A9 Protein on Migration and Proliferation of Microglial Cells
Alzheimer’s disease (AD) is a multifactorial disease affecting aging population worldwide. Neuroinflammation became a focus of research as one of the...
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Human Microglia–Like Cells Differentiated from Monocytes with GM-CSF and IL-34 Show Phagocytosis of α-Synuclein Aggregates and C/EBPβ-Dependent Proinflammatory Activation
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much...
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A survey of the currently known mast cell mediators with potential relevance for therapy of mast cell-induced symptoms
Mast cells (MCs) occupy a central role in immunological as well as non-immunological processes as reflected in the variety of the mediators by which...
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Paternal deprivation induces vigilance-avoidant behavior and accompanies sex-specific alterations in stress reactivity and central proinflammatory cytokine response in California mice (Peromyscus californicus)
RationaleEarly-life stress (ELS) can increase anxiety, reduce prosocial behaviors, and impair brain regions that facilitate emotional and social...
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Mechanistic interplay of different mediators involved in mediating the anti-depressant effect of isoflavones
Depression is one of the most prevalent severe CNS disorders, which negatively affects social lives, the ability to work, and the health of people....
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High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain
BackgroundNeuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation...
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Modulation of inflammatory mediators involved in the antinociceptive and anti-inflammatory effects of a new thioamide derivative: thiocyanoacetamide
Inflammatory pain is part of the body’s defense mechanism and plays an important role in the healing process. Although some drugs are efficient and...
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The effects of berteroin on inflammatory mediators and antioxidant enzymes expression in human periodontal ligament cells
Berteroin is a bioactive substance classified as an isothiocyanate found in cruciferous vegetables such as cabbage, arugula, and salad leaves. In...
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The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population
BackgroundBioactive lipids produced by human cells or by the gut microbiota might play an important role in health and disease. Dietary intakes are...
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A reduction of Syndecan-4 in macrophages promotes atherosclerosis by aggravating the proinflammatory capacity of macrophages
BackgroundCardiovascular diseases (CVDs) are a significant cause of mortality worldwide and are characterized by severe atherosclerosis...
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Systematic review of preclinical studies about effects of Coriandrum sativum L. on inflammatory mediators
This study is designed to systematically review the accessible researches regarding influence of Coriandrum sativum L. on inflammatory mediators...
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Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination
mRNA-based vaccines have been used globally to eradicate the coronavirus-disease 2019 (COVID-19) pandemic. Vaccine efficacy and adverse reactions...
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Polyunsaturated Fatty Acid-Derived Lipid Mediators as Biomarkers in Critical Care
Inflammation is a necessary and beneficial process that protects against injury and infection. However, dysregulated and unrestrained inflammation...
