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Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity
Primates exhibit complex brain structures that augment cognitive function. The neocortex fulfills high-cognitive functions through billions of...
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Primate-specific ZNF808 is essential for pancreatic development in humans
Identifying genes linked to extreme phenotypes in humans has the potential to highlight biological processes not shared with all other mammals. Here,...
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Curiosity: primate neural circuits for novelty and information seeking
For many years, neuroscientists have investigated the behavioural, computational and neurobiological mechanisms that support value-based decisions,...
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Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving to evade host-specific innate immune proteins that differ in...
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Evolutionary scaling and cognitive correlates of primate frontal cortex microstructure
Investigating evolutionary changes in frontal cortex microstructure is crucial to understanding how modifications of neuron and axon distributions...
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Current advances in primate genomics: novel approaches for understanding evolution and disease
Primate genomics holds the key to understanding fundamental aspects of human evolution and disease. However, genetic diversity and functional...
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Activity in primate visual cortex is minimally driven by spontaneous movements
Organisms process sensory information in the context of their own moving bodies, an idea referred to as embodiment. This idea is important for...
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Mapping the primate thalamus: systematic approach to analyze the distribution of subcortical neuromodulatory afferents
Neuromodulatory afferents to thalamic nuclei are key for information transmission and thus play critical roles in sensory, motor, and limbic...
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Mapping the primate thalamus: historical perspective and modern approaches for defining nuclei
The primate thalamus has been subdivided into multiple nuclei and nuclear groups based on cytoarchitectonic, myeloarchitectonic, connectional,...
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Neural Correlates of Spatial Navigation in Primate Hippocampus
The hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that...
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Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model
Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP + in the brain causes permanent Parkinson’s disease-like...
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Anatomical organization of forebrain circuits in the primate
The primate forebrain is a complex structure. Thousands of connections have been identified between cortical areas, and between cortical and...
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Behavioral read-out from population value signals in primate orbitofrontal cortex
The primate orbitofrontal cortex (OFC) has long been recognized for its role in value-based decisions; however, the exact mechanism linking value...
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Primate brain pattern-based automated Alzheimer's disease detection model using EEG signals
Electroencephalography (EEG) may detect early changes in Alzheimer's disease (AD), a debilitating progressive neurodegenerative disease. We have...
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Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Aggregation of α-synuclein (α-syn) is the cornerstone of neurodegenerative diseases termed synucleinopathies, which include Parkinson’s Disease (PD),...
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Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to...
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STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179
Thyrotropin (TSH) is the master regulator of thyroid gland growth and function. Resistance to TSH (RTSH) describes conditions with reduced...
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Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain
BackgroundParaoxonase 2 (PON2) and neuronal uncoupling proteins (UCP4 and UCP5) possess antioxidant, anti-apoptotic activities and minimize...
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Screening hydrogels for antifibrotic properties by implanting cellularly barcoded alginates in mice and a non-human primate
Screening implantable biomaterials for antifibrotic properties is constrained by the need for in vivo testing. Here we show that the throughput of in...
