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Clinical utility of combined assessments of 4D volumetric perfusion CT, diffusion-weighted MRI and 18F-FDG PET-CT for the prediction of outcomes of head and neck squamous cell carcinoma treated with chemoradiotherapy
BackgroundMultiparametric imaging has been seen as a route to improved prediction of chemoradiotherapy treatment outcomes. Four-dimensional...
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In Vivo Quantitative Whole-Body Perfusion Imaging Using Radiolabeled Copper(II) Bis(Thiosemicarbazone) Complexes and Positron Emission Tomography (PET)
Traditional quantitative perfusion imaging methods require complex data acquisition and analysis strategies; typically require ancillary arterial...
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Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
The recent progress in the development of in vivo biomarkers is rapidly changing how neurodegenerative diseases are conceptualized and diagnosed and...
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The identification and cognitive correlation of perfusion patterns measured with arterial spin labeling MRI in Alzheimer’s disease
BackgroundVascular dysfunction, including cerebral hypoperfusion, plays an important role in the pathogenesis and progression of Alzheimer’s disease...
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Advances in PET imaging of cancer
Molecular imaging has experienced enormous advancements in the areas of imaging technology, imaging probe and contrast development, and data quality,...
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PET/MR imaging of inflammation in atherosclerosis
Myocardial infarction, stroke, mental disorders, neurodegenerative processes, autoimmune diseases, cancer and the human immunodeficiency virus impact...
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Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alterations in Alzheimer’s disease
BackgroundQuantitative transport mapping (QTM) of blood velocity, based on the transport equation has been demonstrated higher accuracy and...
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Predicting pathological complete response (pCR) after stereotactic ablative radiation therapy (SABR) of lung cancer using quantitative dynamic [18F]FDG PET and CT perfusion: a prospective exploratory clinical study
BackgroundStereotactic ablative radiation therapy (SABR) is effective in treating inoperable stage I non-small cell lung cancer (NSCLC), but imaging...
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Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is associated with alterations in cortical perfusion that correlate with cognitive impairment. Recently, neural...
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18F-FDG PET and a classifier algorithm reveal a characteristic glucose metabolic pattern in adult patients with moyamoya disease and vascular cognitive impairment
Vascular cognitive impairment (VCI) is a critical issue in moyamoya disease (MMD). However, the glucose metabolic pattern in these patients is still...
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Implications of Post-recanalization Perfusion Deficit After Acute Ischemic Stroke: a Scoping Review of Clinical and Preclinical Imaging Studies
The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood flow through recanalization of the occluded vessel....
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Synaptic loss and its association with symptom severity in Parkinson’s disease
Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments....
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Novel non-MRI imaging techniques for primary diagnosis of prostate cancer: micro-ultrasound, contrast-enhanced ultrasound, elastography, multiparametric ultrasound, and PSMA PET/CT
BackgroundMultiparametric magnetic resonance imaging (mpMRI) provides enhanced diagnostic accuracy in the detection of prostate cancer, but is not...
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Molecular Imaging of Cerebrovascular Reactivity
Positron emission tomography (PET) with [15O]H2O is the clinical reference standard for assessment of cerebrovascular reactivity (CVR). This...
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Myocardial Perfusion Simulation for Coronary Artery Disease: A Coupled Patient-Specific Multiscale Model
Patient-specific models of blood flow are being used clinically to diagnose and plan treatment for coronary artery disease. A remaining challenge is...
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The Relationship Among Glucose Metabolism, Cerebral Blood Flow, and Functional Activity: a Hybrid PET/fMRI Study
18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) estimate brain activities from...
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Imaging biomarkers for clinical applications in neuro-oncology: current status and future perspectives
Biomarker discovery and development are popular for detecting the subtle diseases. However, biomarkers are needed to be validated and approved, and...
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Spatio-Temporal Characterization of Brain Inflammation in a Non-human Primate Stroke Model Mimicking Endovascular Thrombectomy
Reperfusion therapies in acute ischemic stroke have demonstrated their efficacy in promoting clinical recovery. However, ischemia/reperfusion injury...
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Uses of Human MR and PET Imaging in Research of Neurodegenerative Brain Diseases
In the past decades, many neuroimaging studies have aimed to improve the scientific understanding of human neurodegenerative diseases using MRI and...
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Synthesis and Evaluation of 18F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging
We have previously reported that radiolabeled phosphonium cations accumulate in the mitochondriaMitochondria down a transmembrane potential...
