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Effect of prenatal and early post-natal oxycodone exposure on the reinforcing and antinociceptive effects of oxycodone in adult C57BL/6 J mice
AbstractAbuse of opioids (mu-opioid agonists such as oxycodone) among parents during the gestation and early post-natal period is a concern for the...
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Drug-drug interaction perpetrators of oxycodone in patients with cancer: frequency and clinical relevance
AimOxycodone is known to have numerous drug-drug interactions (DDIs) that can potentially decrease efficacy or lead to adverse drug reactions (ADRs)....
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Effects of CB1 receptor negative allosteric modulator Org27569 on oxycodone withdrawal symptoms in mice
Rationale/ObjectivesTargeting cannabinoid receptor type 1 (CB1R) has shown promise for treating opioid withdrawal symptoms. This study aimed to...
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Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury
The development of physical dependence and addiction disorders due to misuse of opioid analgesics is a major concern with pain therapeutics. We...
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Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study
BackgroundOxycodone active uptake across the blood-brain barrier (BBB) is associated with the putative proton-coupled organic cation (H + /OC)...
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Respiratory effects of oral mitragynine and oxycodone in a rodent model
RationaleKratom derives from Mitragyna speciosa (Korth.), a tropical tree in the genus Mitragyna (Rubiaceae) that also includes the coffee tree....
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Contingent administration of typical and biased kappa opioid agonists reduces cocaine and oxycodone choice in a drug vs. food choice procedure in male rhesus monkeys
RationaleCombinations of mu and kappa-opioid receptor (KOR) agonists have been proposed as analgesic formulations with reduced abuse potential. The...
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The effect of concurrent access to alcohol and oxycodone on self-administration and reinstatement in rats
RationaleAlthough polysubstance use is highly prevalent, preclinical studies that assess voluntary consumption of multiple substances at the same...
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Population Pharmacokinetics and Dosing Simulations of Intravenous Oxycodone for Perioperative Pain Relief in Adult Surgical Patients with Obesity
Background and ObjectiveOxycodone, a semisynthetic thebaine derivative µ-opioid (MOP) receptor agonist, is effective for treating moderate and severe...
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Impact of Adolescent Nicotine Exposure in Pre- and Post-natal Oxycodone Exposed Offspring
Perinatal exposure to prescription opioids pose a critical public health risk. Notably, research has found significant neurodevelopmental and...
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Oxycodone-Related Deaths: The Significance of Pharmacokinetic and Pharmacodynamic Drug Interactions
Background and ObjectivesOxycodone is frequently prescribed as well as detected in postmortem cases. Concurrent use of pharmacodynamically or...
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The kappa-opioid receptor agonist, triazole 1.1, reduces oxycodone self-administration and enhances oxycodone-induced thermal antinociception in male rats
RationaleTriazole 1.1 is a novel kappa-opioid receptor (KOR) agonist reported to produce antinociception without KOR-typical adverse effects. When...
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Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies
A method to reproducibly mill abuse deterrent oxycodone hydrochloride (HCl) extended release (ER) tablets was developed for a nasal insufflation...
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Sex and Estrous Cycle Differences in Analgesia and Brain Oxycodone Levels
Sex differences in opioid analgesia occur in rodents and humans, and could be due to differences in drug and metabolite levels. Thus, we investigated...
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Neurobehavioral Characterization of Perinatal Oxycodone-Exposed Offspring in Early Adolescence
The opioid epidemic has received considerable attention, but the impact on perinatal opioid-exposed (POE) offspring remains underexplored. This study...
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Perinatal oxycodone exposure causes long-term sex-dependent changes in weight trajectory and sensory processing in adult mice
RationaleIn utero opioid exposure is associated with lower weight and a neonatal opioid withdrawal syndrome (NOWS) at birth, along with longer-term...
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Evaluation of tradipitant, a selective NK1 antagonist, on response to oxycodone in humans
RationalePreclinical studies demonstrate that the NK1 receptor is involved in opioid reinforcement and withdrawal expression. Few studies have...
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Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7
Oxycodone is an opioid analgesic that is commonly prescribed to pregnant women to treat moderate-to-severe pain. It has been shown to cross the...
