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PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
Morphine and morphine-6-glucuronide (M6G) produce central nervous system (CNS) effects by activating mu-opioid receptors, while naloxone is used...
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Prediction of naloxone dose in opioids toxicity based on machine learning techniques (artificial intelligence)
BackgroundTreatment management for opioid poisoning is critical and, at the same time, requires specialized knowledge and skills. This study was...
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Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept
Background and ObjectivesNaloxone for opioid overdose treatment can be administered by intravenous injection, intramuscular injection, or intranasal...
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Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
RationaleCorticotropin-releasing factor (CRF), the apical stress-inducing hormone, exacerbates stress and addictive behaviors. TCAP-1 is a peptide...
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Inhibition of the NLRP3 Inflammasome Activation/Assembly through the Activation of the PI3K Pathway by Naloxone Protects Neural Stem Cells from Ischemic Condition
Naloxone is a well-known opioid antagonist and has been suggested to have neuroprotective effects in cerebral ischemia. We investigated whether...
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A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways
Naloxone is a non-selective opiate receptor antagonist that is mainly used in the management of acute opioid overdose or intoxication. Previously,...
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A Novel Faster-Acting, Dry Powder-Based, Naloxone Intranasal Formulation for Opioid Overdose
ObjectiveTo examine the pharmacokinetics and safety of FMXIN001, a new intranasal powder-based naloxone formulation, in comparison to Narcan® nasal...
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Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection
Naloxone and nalmefene were administered to seven research beagle dogs (mean weight approximately 12 kg) at doses of 0.04 mg/kg and 0.014 mg/kg for...
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Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose
PurposeOpioids have been the main factor for drug overdose deaths in the United States. Current naloxone delivery systems are effective in mitigating...
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The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers
PurposeRemifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature...
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Prolonged morphine exposure during adolescence alters the responses of lateral paragigantocellularis neurons to naloxone in adult morphine dependent rats
IntroductionAdolescence is a critical period in brain development, and it is characterized by persistent maturational alterations in the function of...
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Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats
RationaleKratom ( Mitragyna speciosa Korth), a native medicinal plant of Southeast Asia, is proposed to exhibit potential therapeutic value as an...
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The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study
BackgroundTramadol is a widely used synthetic opioid. Substantial research has previously focused on the neurological effects of this drug, while the...
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Mechanistic modeling-guided optimization of microneedle-based skin patch for rapid transdermal delivery of naloxone for opioid overdose treatment
Naloxone, an FDA-approved opioid inhibitor, used to reverse opioid overdose complications has up till date faced challenges associated with its...
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Divergent Electrophysiological Effects of Loperamide and Naloxone in a Sensitive Whole-Heart Model
Several case reports suggest QT prolongation leading to ventricular arrhythmias with fatal outcome after intoxication with the μ-opioid receptor...
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Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner
Opioids, like morphine and naloxone, regulate the proliferation and neuronal differentiation of neural stem cells (NSCs) in a receptor-independent...
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Naloxone Diminishes the Virulence and Modifies the Cellular Immune Responses of BALB/c Mice Infected with Leishmania major
PurposeLeishmania major -infected BALB/c mice display strong susceptibility to the infection due to the induction of Th2 response. The aim of this...
