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NMDA Receptors Methods and Protocols
This fully updated volume explores N-Methyl-D-aspartate receptors (NMDARs), and the structure-function relations, principles, and rules that govern...
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Expression and Purification of Mammalian NMDA Receptor Protein for Functional Characterization
N-methyl-D-aspartate (NMDA) receptors are critical for brain function and serve as drug targets for the treatment of neurological and psychiatric...
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Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here,...
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Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice
Proper regulation of N -methyl- d -aspartate-type glutamate receptor (NMDA receptor) expression is responsible for excitatory synaptic functions in the...
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Modeling and Simulation of the NMDA Receptor at Coarse-Grained and Atomistic Levels
N-Methyl-D-aspartate (NMDA) receptors are glutamate-gated excitatory channels that play essential roles in brain functions. While high-resolution...
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NMDA Glutamate Receptor Expression Activity in Anaplastic Astrocytomas
Objectives . To study the relationship between the expression activity of NMDA glutamate receptors and the proliferative activity and genetic...
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Behavioral Assays Dissecting NMDA Receptor Function in Zebrafish
Zebrafish are a powerful system to study brain development and to dissect the activity of complex circuits. One advantage is that they display...
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Spectrum of NMDA Receptor Variants in Neurodevelopmental Disorders and Epilepsy
N-methyl-D-aspartate receptors (NMDAR) are ligand-gated ion channels mediating excitatory neurotransmission and are important for normal brain...
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The NMDA Receptor System and Developmental Neurotoxicity
The NMDA receptor system has been implicated in the etiology of ketamine-induced developmental neurotoxicity. Prolonged ketamine exposure resulting...
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Selective Cell-Surface Expression of Triheteromeric NMDA Receptors
NMDA-type ionotropic glutamate receptors are critically involved in many brain functions and are implicated in a variety of brain disorders. Seven...
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Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats
Obesity has been linked with the impairment of spatial memory and synaptic plasticity but the molecular mechanisms remained unidentified. Since...
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Live FRET-FLIM Imaging to Study Metabotropic Signaling via the NMDA Receptor
Until recently, NMDA receptor (NMDAR) functions have been attributed to its ability to conduct calcium ions. However, growing evidence demonstrates...
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The Role of NMDA Receptor Subunits in the Effect of Memantine on the Brain of Healthy Animals
The non-competitive NMDA glutamate receptor antagonist memantine has neuroprotective properties and is the first non-cholinergic drug approved for...
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The NMDA receptor antagonists memantine and ketamine as anti-migraine agents
Migraine is a debilitating disorder affecting females more frequently than males. There is some evidence that drugs targeting glutamate receptors:...
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The GluN2B-Trp373 NMDA Receptor Variant is Associated with Autism-, Epilepsy-Related Phenotypes and Reduces NMDA Receptor Currents in Rats
Autism spectrum disorder (ASD) is a neurodevelopmental condition with core clinical features of abnormal communication, social interactions, atypical...
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Human serum-derived α-synuclein auto-antibodies mediate NMDA receptor-dependent degeneration of CNS neurons
BackgroundPresence of autoantibodies against α-synuclein (α-syn AAb) in serum of the general population has been widely reported. That such...
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Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
BackgroundIn our previous study, we showed simvastatin exerts an antidepressant effect and inhibits neuroinflammation. Given the role of synaptic...
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MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist
RationaleMK-801 (dizocilpine) is a non-competitive NMDA receptor antagonist originally explored for anticonvulsant potential. Despite its original...
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Selective Reduction of Ca2+ Entry Through the Human NMDA Receptor: a Quantitative Study by Simultaneous Ca2+ and Na+ Imaging
Excessive Ca 2+ influx through N-methyl-D-aspartate type glutamate receptors (NMDAR) is associated with excitotoxicity and neuronal death, but the...
