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NLRP3 inflammasome activation and NETosis positively regulate each other and exacerbate proinflammatory responses: implications of NETosis inhibition for acne skin inflammation treatment
Inflammasomes are multiprotein complexes involved in the host immune response to pathogen infections. Thus, inflammasomes participate in many...
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Visualizing NETosis Using a Novel Neutrophil Extracellular Trap-Specific Marker
As the most abundant leukocyte in circulation, the neutrophil plays a far-reaching role in maintaining homeostasis. Within the context of disease,...
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Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19
BackgroundHigh levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease...
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Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
BackgroundDysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus erythematosus (SLE)...
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Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis
BackgroundChronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow,...
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Circulating cell free DNA and citrullinated histone H3 as useful biomarkers of NETosis in endometrial cancer
BackgroundCancer mortality is mainly caused by organ failure and thrombotic events. It has been demonstrated that NETosis, a chromatin release...
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Trichinella spiralis excretory/secretory products from adult worms inhibit NETosis and regulate the production of cytokines from neutrophils
Upon encountering exogenous pathogens, polymorphonucleocytes (PMNs) engage in various processes to destroy them, including releasing neutrophil...
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Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells
Neutrophil extracellular traps (NETs) can capture and kill viruses, such as influenza viruses, human immunodeficiency virus (HIV), and respiratory...
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C-type lectins and extracellular vesicles in virus-induced NETosis
Dysregulated formation of neutrophil extracellular traps (NETs) is observed in acute viral infections. Moreover, NETs contribute to the pathogenesis...
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Gene Regulation of Neutrophils Mediated Liver and Lung Injury through NETosis in Acute Pancreatitis
Acute pancreatitis (AP) is one of the most common gastrointestinal emergencies, often resulting in self-digestion, edema, hemorrhage, and even...
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The Role of Neutrophil NETosis in Organ Injury: Novel Inflammatory Cell Death Mechanisms
NETosis is a type of regulated cell death dependent on the formation of neutrophil extracellular traps (NET), where net-like structures of...
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The Effect of Vitamin D3 on Neutrophil Extracellular Trap Formation in High-Glucose Conditions
NETosis, i.e ., the formation of neutrophil extracellular traps (NET), and neutrophil autophagy are important elements in the pathogenesis and the...
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Quantitative evaluation of citrullinated fibrinogen for detection of neutrophil extracellular traps
Activated neutrophils release neutrophil extracellular traps (NETs) composed of chromatin filaments containing bactericidal proteins and enzymes....
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Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Acetaldehyde dehydrogenase 2 ( ALDH2 ) mutations are commonly found in a subgroup of the Asian population. However, the role of ALDH2 in septic acute...
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Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness
BackgroundRadiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory form of arthritis in which tumor necrosis factor (TNF)-α, a potent...
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Non-apoptotic Cell Death Control of Neutrophil Extracellular Trap Formation
Neutrophil extracellular traps (NETs) are networks of chromatin and microbicidal proteins released by neutrophils in response to infection and tissue...
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Fluorescence imaging deformability cytometry: integrating nuclear structure with mechanical phenotyping
Mechanical measurements of cells can provide unique insights into cell state and disease processes. The overall mechanical properties of cells can be...
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Down-regulated miR-146a expression with increased neutrophil extracellular traps and apoptosis formation in autoimmune-mediated diffuse alveolar hemorrhage
BackgroundIncreasing evidences have suggested an important role of microRNAs (miRNAs) in regulating cell death processes including NETosis and...
