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Multiplexed single-cell transcriptome analysis reveals molecular characteristics of monkey pluripotent stem cell lines
Efforts have been made to establish various human pluripotent stem cell lines. However, such methods have not yet been duplicated in non-human...
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Enhanced Beta2-band Oscillations Denote Auditory Hallucination in Schizophrenia Patients and a Monkey Model of Psychosis
An electroencephalographic (EEG) signature of auditory hallucinations (AHs) is important for facilitating the diagnosis and treatment of AHs in...
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Comparative metabolism of fargesin in human, dog, monkey, mouse, and rat hepatocytes
Fargesin, a bioactive lignan derived from Flos Magnoliae, possesses anti-inflammatory, anti-oxidative, anti-melanogenic, and anti-apoptotic effects....
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ChatGPT Applications and Challenges in Controlling Monkey Pox in Pakistan
Generative Pre-trained Transformer-based Chatbot (ChatGPT) is an emerging OpenAI application with its greater role in revolutionizing the world....
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An Improved Monkey Model of Myocardial Ischemic Infarction for Cardiovascular Drug Development
Non-human primate monkey model of myocardial ischemic infarction is precious for translational medicine research. Ligation of the left anterior...
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Production, Testing, and Verification of Lentivirus for Regional Targeting in the Old-World Monkey Brain
Genetic tools in the monkey brain are primarily applied through the injection of viral vectors in adult animals, as germline modification is...
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Cortical adaptation of the night monkey to a nocturnal niche environment: a comparative non-invasive T1w/T2w myelin study
Night monkeys ( Aotus ) are the only genus of monkeys within the Simian lineage that successfully occupy a nocturnal environmental niche. Their...
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Tolerability and tropism of recombinant adeno-associated virus vectors in the African green monkey (Chlorocebus sabaeus) anterior chamber
While many studies have investigated the use of recombinant adeno-associated vectors (rAAV) in the posterior chamber for treatment of inherited...
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Characteristics of the Retention of Color and Monochrome Images in Working Memory in the Monkey Macaca Mulatta
Behavioral experiments were run to assess the ability of rhesus monkeys to retain visual objects differing in shape, color, or a combination of these...
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Effects of Combined Treatment with Compounds Affecting Mitochondria on Physiological Parameters in Old Monkey
Correction of mitochondrial function is a promising direction for modulating aging processes. The effect of NAD + (in the form of its precursor...
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Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17
In this novel large-scale multiplexed immunofluorescence study we comprehensively characterized and compared layer-specific proteomic features within...
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Sex differences in recovery of motor function in a rhesus monkey model of cortical injury
BackgroundStroke disproportionately affects men and women, with women over 65 years experiencing increased severity of impairment and higher...
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Comparison of Various Approaches to Translate Non-Linear Pharmacokinetics of Monoclonal Antibodies from Cynomolgus Monkey to Human
Background and ObjectivesThe prediction of pharmacokinetics of monoclonal antibodies (mAbs) exhibiting non-linear pharmacokinetics in preclinical...
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Co-editing PINK1 and DJ-1 Genes Via Adeno-Associated Virus-Delivered CRISPR/Cas9 System in Adult Monkey Brain Elicits Classical Parkinsonian Phenotype
Whether direct manipulation of Parkinson’s disease (PD) risk genes in the adult monkey brain can elicit a Parkinsonian phenotype remains an unsolved...
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mRNA expression analysis of the hippocampus in a vervet monkey model of fetal alcohol spectrum disorder
BackgroundFetal alcohol spectrum disorders (FASD) are common, yet preventable developmental disorders that stem from prenatal exposure to alcohol....
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Ketamine reduces temporal expectation in the rhesus monkey
RationaleKetamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor,...
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Application of blood microsampling in cynomolgus monkey and demonstration of equivalent monoclonal antibody PK parameters compared to conventional sampling
PurposeThe purpose of this study was to evaluate the suitability of whole blood microsampling procedures in non-human primate (NHP) to support...
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Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry
There is an urgent demand to develop new technologies to characterize immunogenicity to biotherapeutics. Here, we developed an immunocapture LC-MS...
