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Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer
BackgroundColorectal cancer (CRC) is one of the three major cancers in the world and is the cancer with the most liver metastasis. The present study...
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Role of Metallothionein-1 and Metallothionein-2 in the Neuroprotective Mechanism of Sevoflurane Preconditioning in Mice
This study investigated the protective effects and mechanisms of sevoflurane preconditioning (SPC) on neurons in ischemic mice. After SPC, mice were...
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Lead and Excitotoxicity
Lead (Pb2+) is a known neurotoxicant that impairs learning and memory. However, the mechanism through which it impairs learning and memory is not...
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Biomarkers of Neurotoxicity Inform Mechanisms of Vulnerability and Resilience in Dopaminergic Neurons
Vulnerable pathways and associated stress biomarkers characteristic of neurons may be used to identify the chemical triggers for neurodegenerative...
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Metallothionein 1 Overexpression Does Not Protect Against Mitochondrial Disease Pathology in Ndufs4 Knockout Mice
Mitochondrial diseases (MD), such as Leigh syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known...
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Oral Exposure to Lead Acetate for 28 Days Reduces the Number of Neural Progenitor Cells but Increases the Number and Synaptic Plasticity of Newborn Granule Cells in Adult Hippocampal Neurogenesis of Young-Adult Rats
Lead (Pb) causes developmental neurotoxicity. Developmental exposure to Pb acetate (PbAc) induces aberrant hippocampal neurogenesis by increasing or...
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Lead and Excitotoxicity
Lead (Pb2+) is a known neurotoxicant that impairs learning and memory. However, the mechanism through which it impairs learning and memory is not...
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Biomarkers of Neurotoxicity Inform Mechanisms of Vulnerability and Resilience in Dopaminergic Neurons
Vulnerable pathways and associated stress biomarkers characteristic of neurons may be used to identify the chemical triggers for neurodegenerative...
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Modulatory effects of phenolics extract of Costus afer leaves on cadmium induced nephrotoxicity and hepatoxicity in Wistar rats
ObjectivesEnvironmental exposure to cadmium is a major public health concern and available synthetic drugs for treating cadmium poisoning are...
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Developmental Exposure of Mice to T-2 Toxin Increases Astrocytes and Hippocampal Neural Stem Cells Expressing Metallothionein
We previously reported that developmental exposure to T-2 toxin caused transient disruption of the hippocampal neurogenesis targeting neural stem...
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The role of noble bumblebee (Bombus terrestris) queen glycosaminoglycan in aged rat and gene expression profile based on DNA microarray
Glycosaminoglycans (GAGs) have been used to diminish the deleterious effects associated with aging by preventing the destruction of cartilage, bone,...
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Molecular Mechanisms of Metal-Induced Carcinogenesis
Occupational and environmental exposures to metals are strongly associated with an increased risk of various cancers. Although carcinogenesis caused...
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Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s
BackgroundThe molecular drivers of early sporadic Parkinson’s disease (PD) remain unclear, and the presence of widespread end stage pathology in late...
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Neurodegenerative Aspects of Multiple System Atrophy
Multiple system atrophy (MSA) closely resembles Parkinson’s disease clinically but with a range of autonomic signs in addition to motor symptoms,...
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Differential gene expression of 3D primary human airway cultures exposed to cigarette smoke and electronic nicotine delivery system (ENDS) preparations
BackgroundAcute exposure to cigarette smoke alters gene expression in several biological pathways such as apoptosis, immune response, tumorigenesis...
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Metalle
Hinsichtlich ihrer Toxizität für den Menschen weisen Metalle einige Gemeinsamkeiten auf. Bei Vergiftungen mit Metallen können lokale...
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Key genes and molecular mechanisms related to Paclitaxel Resistance
Paclitaxel is commonly used to treat breast, ovarian, lung, esophageal, gastric, pancreatic cancer, and neck cancer cells. Cancer recurrence is...
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Toxicometallomics of Cadmium, Manganese and Arsenic with Special Reference to the Roles of Metal Transporters
The transport systems for metals play crucial roles in both the physiological functions of essential metals and the toxic effects of hazardous metals...
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Biochemical Mechanistic Pathway of Cell Death Induced by Metal-Based Chemotherapeutic Agents
A large plethora of metal complexes that could act as potent anticancer chemotherapeutic agents have been designed and developed in the recent past...
