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Heavy Metal Scavenger Metallothionein Rescues Against Cold Stress-Evoked Myocardial Contractile Anomalies Through Regulation of Mitophagy
Cold stress prompts an increased prevalence of cardiovascular morbidity yet the underneath machinery remains unclear. Oxidative stress and autophagy...
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Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response
Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This...
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Metallothionein 2A (MT2A) controls cell proliferation and liver metastasis by controlling the MST1/LATS2/YAP1 signaling pathway in colorectal cancer
BackgroundColorectal cancer (CRC) is one of the three major cancers in the world and is the cancer with the most liver metastasis. The present study...
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Metallothionein-3 is a multifunctional driver that modulates the development of sorafenib-resistant phenotype in hepatocellular carcinoma cells
Background & aimsMetallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has...
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Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain
BackgroundWe previously reported a correlation between small doses of oxaliplatin penetrating onto the spinal cord and acute pain after chemotherapy....
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Role of Metallothionein-1 and Metallothionein-2 in the Neuroprotective Mechanism of Sevoflurane Preconditioning in Mice
This study investigated the protective effects and mechanisms of sevoflurane preconditioning (SPC) on neurons in ischemic mice. After SPC, mice were...
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Metallothionein-3 as a multifunctional player in the control of cellular processes and diseases
Transition metals, such as iron, copper, and zinc, play a very important role in life as the regulators of various physiochemical reactions in cells....
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Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β1-42
BackgroundIt is possible that increased synthesis of metallothioneins (MTs), Zn 2+ -binding proteins is linked with the protective effect of...
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Selenium biofortification improves bioactive composition and antioxidant status in Plantago ovata Forsk., a medicinal plant
BackgroundSelenium (Se) is an essential micronutrient for humans, but its deficiency as well as toxicity affects large number of people worldwide. Pla...
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The role of zinc supplementation on the metallothionein system in children with autism spectrum disorder
The present research was carried out to elucidate the role of zinc (Zn) supplementation on the plasma concentration and gene expression, as well as...
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Metallothionein induction attenuates the progression of lung injury in mice exposed to long-term intermittent hypoxia
BackgroundIntermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is prevalent in older adults and associated with inflammation. We...
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Lead and Excitotoxicity
Lead (Pb2+) is a known neurotoxicant that impairs learning and memory. However, the mechanism through which it impairs learning and memory is not...
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Metallothionein 1 Overexpression Does Not Protect Against Mitochondrial Disease Pathology in Ndufs4 Knockout Mice
Mitochondrial diseases (MD), such as Leigh syndrome (LS), present with severe neurological and muscular phenotypes in patients, but have no known...
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Oxidative stress and neuroimmune proteins in a mouse model of autism
Oxidative stress including decreased antioxidant enzyme activities, elevated lipid peroxidation, and accumulation of advanced glycation end products...
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Biomarkers of Neurotoxicity Inform Mechanisms of Vulnerability and Resilience in Dopaminergic Neurons
Vulnerable pathways and associated stress biomarkers characteristic of neurons may be used to identify the chemical triggers for neurodegenerative...
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Fetal Neuroprotective Mechanism of Maternal Magnesium Sulfate: Proteomic Analysis
Mg supplementation has been shown to protect preterm fetuses from white and gray matter damage, but the mechanism is unclear. The purpose of this...
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Oral Exposure to Lead Acetate for 28 Days Reduces the Number of Neural Progenitor Cells but Increases the Number and Synaptic Plasticity of Newborn Granule Cells in Adult Hippocampal Neurogenesis of Young-Adult Rats
Lead (Pb) causes developmental neurotoxicity. Developmental exposure to Pb acetate (PbAc) induces aberrant hippocampal neurogenesis by increasing or...
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Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
BackgroundThe accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins...
