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Rodent maze studies: from following simple rules to complex map learning
More than 100 years since the first maze designed for rodent research, researchers now have the choice of a variety of mazes that come in many...
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Sex Differences in the Influences of Early Proinflammatory Stress on Learning and Memory in Adult Rats in the Morris Water Maze
The effects of early proinflammatory stress induced by administration of bacterial lipopolysaccharide (LPS) on the days 3 and 5 of life on learning...
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Ability to Discriminate Visual Signals in the Morris Water Maze in High- and Low-Impulsivity Rats
High-impulsivity (HI) rats learned to locate a visible platform bearing a special stimulus object (a bannerette) in the Morris water maze more...
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Effects of Ovariectomy on Learning in Rats in Health and after Early Proinflammatory Stress
We report here studies on the effects of ovariectomy (OE) in females performed at age 35 days on the development and extinction of a conditioned fear...
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Salifen Prevents Perinatal Hypoxia-Induced Cognitive Impairments and Changes in the Expression of GABAB Receptors in the Rat Neocortex
We report here a study examining the effects of acute normobaric hypoxia in the early postnatal period of development (postnatal day 2) on learning...
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Effect of a Salvia officinalis and Hypericum perforatum mixture on improving memory and cognitive decline
In this study, we explored the effects of herbal mixture containing Sage ( Salvia officinalis ) and St. John’s Wort ( Hypericum perforatum ) on cognitive...
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The ameliorative effect of midazolam on empathy-like behavior in old rats
Although studies suggest that cognitive functions in the elderly are impaired, elderly people tend to be more successful and wiser in solving...
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Per2 Expression Regulates the Spatial Working Memory of Mice through DRD1-PKA-CREB Signaling
Several individuals worldwide show cognitive impairment due to various reasons, including a prolonged lifespan and an altered lifestyle. Various...
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Hippocampal Inhibitory Synapsis Deficits Induced by α5-Containing GABAA Receptors Mediate Chronic Neuropathic Pain–Related Cognitive Impairment
Chronic neuropathic pain often leads to cognitive impairment, but the exact mechanism remains unclear. Gamma-aminobutyric acid A receptors (GABA A Rs)...
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Extreme Glycemic Fluctuations Debilitate NRG1, ErbB Receptors and Olig1 Function: Association with Regeneration, Cognition and Mood Alterations During Diabetes
Neuronal regeneration is crucial for maintaining intact neural interactions for perpetuation of cognitive and emotional functioning. The NRG1-ErbB...
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Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction
Neuroinflammation is a critical driver in the pathogenesis and progression of neurodegenerative disorders. Dammarane sapogenins (DS), a...
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Aqueous extract of Piper betle L. leaf and Areca catechu L. nut protects against pentylenetetrazole-induced seizures and positively modulates cognitive function in adult Zebrafish
Piper betle L. (BL) is a popular medicinal plant in Asia. BL has been used as a traditional medicine to treat various health conditions. Areca catechu ...
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7, 8-dihydroxyflavone Ameliorates Cholinergic Dysfunction, Inflammation, Oxidative Stress, and Apoptosis in a Rat Model of Vascular Dementia
Vascular dementia (VD) is a degenerative cerebrovascular disorder associated with progressive cognitive decline. Previous reports have shown that...
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Epigallocatechin-3-gallate improves chronic alcohol-induced cognitive dysfunction in rats by interfering with neuro-inflammatory, cell death and oxido-nitrosative cascade
Alcohol consumption for a longer period of time is linked with neuronal damage and an increase in inflammatory signaling resulting in cell death and...
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Proof of Concept for the Use of Immersive Virtual Reality in Upper Limb Rehabilitation of Multiple Sclerosis Patients
Multiple sclerosis (MS) is a debilitating disease which gradually reduces motor function and mobility. Virtual reality (VR) has been successfully...
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Behavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models
RationaleThe dopamine D4 receptors (DRD4) play a key role in numerous brain functions and are involved in the pathogenesis of various psychiatric...
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Biochemical, Biomarker, and Behavioral Characterization of the GrnR493X Mouse Model of Frontotemporal Dementia
Heterozygous loss-of-function mutations in the progranulin gene ( GRN ) are a major cause of frontotemporal dementia due to progranulin...
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Prenatal PM2.5 exposure impairs spatial learning and memory in male mice offspring: from transcriptional regulation to neuronal morphogenesis
BackgroundAs one of the environmental risk factors for human health, atmospheric fine particulate matter (PM 2.5 ) contributes to cognitive...
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Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol
Diabetes mellitus (DM) is a type of metabolic disease characterized by chronic hyperglycemia, which can lead to different degrees of cognitive...
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Assessing cognitive decline in the aging brain: lessons from rodent and human studies
As life expectancy continues to increase worldwide, age-related dysfunction will largely impact our societies in the future. Aging is well...
