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Personalized Pressure Conditions and Calibration for a Predictive Computational Model of Coronary and Myocardial Blood Flow
Predictive modeling of hyperemic coronary and myocardial blood flow (MBF) greatly supports diagnosis and prognostic stratification of patients...
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A deep learning-based fully automatic and clinical-ready framework for regional myocardial segmentation and myocardial ischemia evaluation
Myocardial ischemia diagnosis with CT perfusion imaging (CTP) is important in coronary artery disease management. Traditional analysis procedure is...
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Biomarkers of Myocardial Fibrosis in Diabetes, Echocardiography, and Magnetic Resonance Imaging
Diabetes mellitus (DM) is associated with cardiomyopathy. Cardiomyopathy in DM can be from ischemic heart disease or related purely to DM-related... -
Quantification of Myocardial Blood Flow by Machine Learning Analysis of Modified Dual Bolus MRI Examination
Contrast-enhanced magnetic resonance imaging (MRI) is a promising method for estimating myocardial blood flow (MBF). However, it is often affected by...
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Biomarkers of Myocardial Fibrosis in Diabetes, Echocardiography, and Magnetic Resonance Imaging
Diabetes mellitus (DM) is associated with cardiomyopathy. Cardiomyopathy in DM can be from ischemic heart disease or related purely to DM-related... -
Development of a dedicated 3D printed myocardial perfusion phantom: proof-of-concept in dynamic SPECT
We aim to facilitate phantom-based (ground truth) evaluation of dynamic, quantitative myocardial perfusion imaging (MPI) applications. Current MPI...
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Myocardial Perfusion Simulation for Coronary Artery Disease: A Coupled Patient-Specific Multiscale Model
Patient-specific models of blood flow are being used clinically to diagnose and plan treatment for coronary artery disease. A remaining challenge is...
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Fluid Dynamics–Derived Parameters in Coronary Vessels
Continued development in the field of cardiovascular modeling over the past few years has contributed to the production of precise three-dimensional... -
Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration
Myocardial Brg1 is essential for heart regeneration in zebrafish, but it remains unknown whether and how endothelial Brg1 plays a role in heart...
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Role of Microfluidics and Nanofluidics in Managing CAD
A comprehensive understanding of interaction between molecules and pathways is essential to understand complex biological systems and their... -
Clinical significance of PET-CT coronary flow reserve in diagnosis of non-obstructive coronary artery disease
ObjectiveTo improve current knowledge of coronary flow reserve and non-obstructive coronary artery disease in terms of definition, features and...
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Quantification of neurons in the hippocampal formation of chimpanzees: comparison to rhesus monkeys and humans
The hippocampal formation is important for higher brain functions such as spatial navigation and the consolidation of memory, and it contributes to...
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The association of 18F-FDG PET/CT and biomarkers in confirming coronary microvascular dysfunction
ObjectiveThe purpose of this study is to evaluate the association between PET/CT CFR and biomarkers combined in confirming the diagnosis of coronary...
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Imaging of αvβ3 integrin expression in experimental myocardial ischemia with [68Ga]NODAGA-RGD positron emission tomography
BackgroundRadiolabeled RGD peptides detect α v β 3 integrin expression associated with angiogenesis and extracellular matrix remodeling after...
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Myocardial Blood Flow as a Biomarker
Myocardial blood flow (MBF) is an emerging and important biomarker of cardiovascular disease. Its absolute quantification in physical unit (ml/min/g)... -
Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging
Quantitative cardiovascular magnetic resonance (CMR) imaging can be used to characterize fibrosis, oedema, ischaemia, inflammation and other disease...
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Gendered Innovations in the Study of Cardiovascular Diseases
The chapter summarizes modern knowledge on gender aspects of major cardiovascular diseases starting from basic research. It covers arterial... -
Sex Differences in the Coronary System
Cardiovascular disease remains the leading cause of morbidity and mortality for both women and men. Emerging evidence supports that ischemic heart... -
Myocardial Blood Flow as a Biomarker
Myocardial blood flow (MBF) is an emerging and important biomarker of cardiovascular disease. Its absolute quantification in physical unit (ml/min/g)...