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The Neurobiological Role of Lithium Salts
Lithium salts have been the mainstay of treatment for bipolar disorder for more than 50 years, since approval by the FDA in 1970 for the treatment of...
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Lithium, the gold standard drug for bipolar disorder: analysis of current clinical studies
Lithium is the gold standard drug in the treatment of bipolar disorder. Despite increasing scientific interest, relatively few patients with bipolar...
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Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT): A Preventable Cerebellar Disorder
We report a case study of a 60-year-old man with bipolar disorder on stable lithium treatment who developed severe toxicity while admitted to ICU...
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Mood and behavior regulation: interaction of lithium and dopaminergic system
Lithium is one of the most effect mood-stabilizing drugs prescribed especially for bipolar disorder. Lithium has wide range effects on different...
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Clozapine but not lithium reverses aberrant tyrosine uptake in patients with bipolar disorder
RationaleAvailability of the dopamine and noradrenaline precursor tyrosine is critical for normal functioning, and deficit in tyrosine transport...
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Lithium-Modified Sorbent: Effects on Hemostatic Responses In Vitro
The effects of a lithium-modified sorbent based on aluminum oxide and polydimethylsiloxane (Al 2 O 3 @PDMS/Li) and a lithium-free sorbent (Al 2 O 3 @PDMS) on...
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Lithium chloride treatments in free flying honey bee colonies: efficacy, brood survival, and within-colony distribution
The efficacy of various lithium chloride (LiCl) applications in eradicating the parasitic mite Varroa destructor in honey bee colonies was...
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Abelson Helper Integration Site 1 haplotypes and peripheral blood expression associates with lithium response and immunomodulation in bipolar patients
RationaleIn bipolar disorder (BD), immunological factors play a role in the pathogenesis and treatment of the illness. Studies showed the potential...
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Analysis on in vitro effect of lithium on telomere length in lymphoblastoid cell lines from bipolar disorder patients with different clinical response to long-term lithium treatment
BackgroundIt has been suggested that bipolar disorder (BD) is associated with clinical and biological features of accelerated aging. In our previous...
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The Mood Stabilizer Lithium Slows Down Synaptic Vesicle Cycling at Glutamatergic Synapses
Lithium is a mood stabilizer broadly used to prevent and treat symptoms of mania and depression in people with bipolar disorder (BD). Little is...
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The Expression of Markers of Acute Kidney Injury Kim1 and NGAL after Administration of High Doses of Lithium Carbonate in Mice with Engrafted Skin Melanoma B16
The expression of marker proteins of acute kidney injury after administration of high doses of lithium carbonate was assessed to evaluate the...
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Effect of lithium administration on brain activity under an emotion regulation paradigm in healthy participants: a functional magnetic resonance imaging study
RationaleEmotion regulation (ER) difficulties have been previously described in bipolar disorder (BD). Whilst lithium has been shown to be effective...
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Hybrid Cathode Lithium Battery Discharge Simulation for Implantable Cardioverter Defibrillators Using a Coupled Electro-Thermal Dynamic Model
This paper explores the effect of the load imposed by implantable cardioverter defibrillators (ICDs) on their lithium battery power sources longevity...
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Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and represents a challenge for clinicians. The present...
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Increased levels of lipid and protein oxidation in rat prefrontal cortex after treatment by lithium, valproic acid, and olanzapine
Oxidative stress is widely accepted to contribute to the pathogenesis of several psychiatric diseases. Many antipsychotic drugs and mood stabilizers...
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Public Understanding of Geoethics Dilemmas: A survey on Lithium Exploitation
Lithium holds high potential in technology, mainly green technologies, presenting notable economic and environmental importance. In the north of...
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Changes in the Midbrain Neurobiological Responses to Lithium Chloride under Inflammatory Conditions
AbstractEffectiveness of psychotropic drugs can be altered under inflammation however the mechanisms of the possible changes remain unclear. In order...
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Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria
The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the monocarboxylate transporter symport system suppresses...
