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ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis
Reactive oxygen species (ROS) mediate lipid peroxidation and produce 4-hydroxynonenal and other related products, which play an important role in the...
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Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain
Lipid peroxidation is a process of oxidative degradation of cellular lipids that is increasingly recognized as an important factor in the...
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Porous Se@SiO2 nanospheres alleviate diabetic retinopathy by inhibiting excess lipid peroxidation and inflammation
BackgroundLipid peroxidation is a characteristic metabolic manifestation of diabetic retinopathy (DR) that causes inflammation, eventually leading to...
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ALDH3B1 protects interfollicular epidermal cells against lipid peroxidation via the NRF2 pathway
Reactive oxygen species (ROS) production is critical for the initiation of wound repair; however, persistently high levels of ROS can lead to lipid...
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Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1
Psychological stress increases the susceptibility to herpes simplex virus type 1 (HSV-1) infection. There is no effective intervention due to the...
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Genipin protects against acute liver injury by abrogating ferroptosis via modification of GPX4 and ALOX15-launched lipid peroxidation in mice
It is essential to further characterize liver injury aimed at developing novel therapeutic approaches. This study investigated the mechanistic basis...
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AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation
BackgroundOxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their...
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Polyphyllin I induces rapid ferroptosis in acute myeloid leukemia through simultaneous targeting PI3K/SREBP-1/SCD1 axis and triggering of lipid peroxidation
Acute myeloid leukemia (AML) is a malignant disease that is difficult to completely cure. Polyphyllin I (PPI), a steroidal saponin isolated from Paris...
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DNA Lesions Induced by Lipid Peroxidation Products in Cancer Progression
Lipid peroxidation, initiated by reactive oxygen species or enzymes, originates a variety of electrophiles able to modify biomolecules, including...
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Small molecule–engineered nanoassembly for lipid peroxidation–amplified photodynamic therapy
Photodynamic therapy (PDT), extensively explored as a non-invasive and spatio-temporal therapeutic modality for cancer treatment, encounters...
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Glycitein prevents reserpine-induced depression and associated comorbidities in mice: modulation of lipid peroxidation and TNF-α levels
Depression is a debilitating mood disorder affecting millions worldwide and continues to pose a significant global health burden. Due to the...
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Mechanistic and Therapeutic Crosstalk of Lipid Peroxidation in Oxidative Stress and Breast Cancer
Breast cancer is the most frequently diagnosed and leading cancer with the highest morbidity worldwide in women. In the past few decades, researchers...
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Mechanistic and Therapeutic Crosstalk of Lipid Peroxidation in Oxidative Stress and Breast Cancer
Breast cancer is the most frequently diagnosed and leading cancer with the highest morbidity worldwide in women. In the past few decades, researchers...
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Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammation
BackgroundExposure to particulate matter air pollution is associated with an increased risk of cardiovascular mortality in patients with chronic...
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Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes
Parkinson’s disease (PD) is the second most common neurodegenerative disorder . Progressive loss of dopaminergic neurons in the substantia nigra (SN)...
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DNA Lesions Induced by Lipid Peroxidation Products in Cancer Progression
Lipid peroxidation, initiated by reactive oxygen species or enzymes, originates a variety of electrophiles able to modify biomolecules, including...
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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue...
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Assessing the Contributions of Lipid Profile and Oxidative Lipid Damage to Carcinogenesis
Lipids are integral components in the body, performing various structural and functional roles – as energy reservoirs, insulators, cell membrane...
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An Aggregation-induced Emission Probe to Detect the Viscosity Change in Lipid Droplets during Ferroptosis
Ferroptosis is a recently identified form of cell death characterized by iron-dependent lipid peroxidation. Understanding the effects of lipid...
