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The kainate receptor GluK2 mediates cold sensing in mice
Thermosensors expressed in peripheral somatosensory neurons sense a wide range of environmental temperatures. While thermosensors detecting cool,...
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Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy
The most well-known type of focal epilepsy that is resistant to existing treatments is temporal lobe epilepsy (TLE), with seizure foci in various...
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Alterations in Receptor Genes in Huntington’s Disease
In this chapter, we explored the alterations in receptor genes associated with Huntington’s disease (HD). The dysfunction and composition of receptor...
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Glutamate Receptor Auxiliary Subunits and Interacting Protein Partners in the Cerebellum
AMPA- and kainate-type glutamate receptors play a central role in excitatory signaling and synaptic plasticity in the cerebellum. Considerable...
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An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention
Temporal lobe epilepsy is the most common drug-resistant epilepsy. To cure epilepsy, drugs must target the mechanisms at the origin of seizures....
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Intrathecal Injection of GRIP-siRNA Reduces Postoperative Synaptic Abundance of Kainate Receptor GluK2 Subunits in Rat Dorsal Horns and Pain Hypersensitivity
The mechanisms underlying postoperative pain differ from the inflammatory or neuropathic pain. Previous studies have demonstrated that intrathecal...
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Interneuronal GluK1 kainate receptors control maturation of GABAergic transmission and network synchrony in the hippocampus
Kainate type glutamate receptors (KARs) are strongly expressed in GABAergic interneurons and have the capability of modulating their functions via...
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PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway
BackgroundPyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN) selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also...
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Mechanisms of AMPA Receptor Inhibition by Diminazene
Diminazene is an anti-infection agent for animals and is a member of the diarylamidine group. This study reports the first detection of its...
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Gradients of neurotransmitter receptor expression in the macaque cortex
Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization...
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Deciphering the Biophysical Properties of Ion Channel Gating Pores by Coumarin–Benzodiazepine Hybrid Derivatives: Selective AMPA Receptor Antagonists
In the 1980s, the identification of specific pharmacological antagonists played a crucial role in enhancing our comprehension of the physiological...
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The Anticonvulsant Effect of a Novel Indole-Related Compound in the Kainate-Induced Status Epilepticus in Mice: The Role of the Antioxidant and Anti-inflammatory Mechanism
We synthesized a series of novel indole compounds containing aroylhydrazone moieties and evaluated them in mice to check their anticonvulsant...
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The NMDA Receptor System and Developmental Neurotoxicity
The NMDA receptor system has been implicated in the etiology of ketamine-induced developmental neurotoxicity. Prolonged ketamine exposure resulting...
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Glutamatergic Pathways and Receptors
Glutamate is a major excitatory neurotransmitter in the vertebrate brain and is utilized at distinct synapses in the cerebellum. Glutamate released...
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IEM-1925, a Glutamate Receptor Channel Blocker, Increases the Latent Period and Decreases the Duration of Status Epilepticus in Rats in a Lithium-Pilocarpine Model of Epilepsy
Chronic experiments on male Wistar and Krushinskii–Molodkina rats, the latter having an inherited predisposition for audiogenic convulsions,...
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Live FRET-FLIM Imaging to Study Metabotropic Signaling via the NMDA Receptor
Until recently, NMDA receptor (NMDAR) functions have been attributed to its ability to conduct calcium ions. However, growing evidence demonstrates...
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Ketamine and Other Glutamate Receptor Antagonists As Fast-Actin
The glutamate hypothesis of depression was prominently emerging in this decade. Evidence has shown that low-dose ketamine infusion or intranasal...
