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A framework for the evaluation and reporting of incidental findings in clinical genomic testing
Currently, there are no widely accepted recommendations in the genomics field guiding the return of incidental findings (IFs), defined here as...
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GBA/GBN-position on the feedback of incidental findings in biobank-based research: consensus-based workflow for hospital-based biobanks
Incidental research findings pose a considerable challenge to hospital-based research biobanks since they are acting as intermediaries between...
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Return of non-ACMG recommended incidental genetic findings to pediatric patients: considerations and opportunities from experiences in genomic sequencing
BackgroundThe uptake of exome/genome sequencing has introduced unexpected testing results (incidental findings) that have become a major challenge...
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Incidental findings from cancer next generation sequencing panels
Next-generation sequencing (NGS) technologies have facilitated multi-gene panel (MGP) testing to detect germline DNA variants in hereditary cancer...
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Characteristics of incidental prostate cancer in the United States
BackgroundData regarding North-American incidental (cT1a/b) prostate cancer (PCa) patients is scarce. To address this, incidental PCa characteristics...
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Incidental finding of leukaemia in circulating tumour DNA— the importance of a molecular tumour board
As the use of liquid biopsies are increasing across multiple indications in cancer medicine, the detection of incidental findings on circulating...
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Incidental germline findings during molecular profiling of tumor tissues for precision oncology: molecular survey and methodological obstacles
BackgroundA fraction of patients referred for complex molecular profiling of biopsied tumors may harbor germline variants in genes associated with...
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Incidental pathogenic germline alterations detected through liquid biopsy in patients with solid tumors: prevalence, clinical utility and implications
Liquid biopsy, a minimally invasive approach for detecting tumor biomarkers in blood, has emerged as a leading-edge technique in cancer precision...
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Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson
Incidental Lewy body disease (ILBD) is a neuropathological diagnosis of brains with Lewy bodies without clinical neuropsychiatric symptoms....
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Incidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline
BackgroundThe etiology of idiopathic normal pressure hydrocephalus (iNPH) remains unclear. Little is known about the pre-symptomatic stage. This...
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Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
BackgroundParkinson’s disease (PD) is a progressive neurodegenerative disorder associated with a loss of dopaminergic (DA) neurons. Despite...
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Incidental irradiation of the regional lymph nodes during deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a dosimetric analysis
BackgroundRadiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of...
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Germline heterozygous exons 8–11 pathogenic BARD1 gene deletion reported for the first time in a family with suspicion of a hereditary colorectal cancer syndrome: more than an incidental finding?
BackgroundColorectal cancer (CRC) is a highly prevalent disease in developed countries. Inherited Mendelian causes account for approximately 5% of...
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Frequency of actionable secondary findings in 7472 Korean genomes derived from the National Project of Bio Big Data pilot study
Exome and genome sequencing (ES/GS) in genetic medicine and research leads to discovering genomic secondary findings (SFs) unrelated to the purpose...
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The attitude and behaviors of the different spheres of the community of the United Arab Emirates toward the clinical utility and bioethics of secondary genetic findings: a cross-sectional study
IntroductionGenome sequencing has utility, however, it may reveal secondary findings. While Western bioethicists have been occupied with managing...
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Expectations, needs and mid-term outcomes in people accessing to secondary findings from ES: 1st French mixed study (FIND Study)
Generation and subsequently accessibility of secondary findings (SF) in diagnostic practice is a subject of debate around the world and particularly...
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Sequence variants in malignant hyperthermia genes in Iceland: classification and actionable findings in a population database
Malignant hyperthermia (MH) susceptibility is a rare life-threatening disorder that occurs upon exposure to a triggering agent. MH is commonly due to...
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Public interest in unexpected genomic findings: a survey study identifying aspects of sequencing attitudes that influence preferences
We describe public preferences for unexpected genomic findings and explore predictors of preferences using an online survey in an Eastern Canadian...
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