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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy
Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy....
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Selective vulnerability of hippocampal sub-regions in patients with subcortical vascular mild cognitive impairment
Early diagnosis of subcortical vascular mild cognitive impairment (svMCI) is clinically essential because it is the most reversible subtype of all...
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Effects of childhood maltreatment and major depressive disorder on functional connectivity in hippocampal subregions
Major Depressive Disorder (MDD) with childhood maltreatment is a prevalent clinical phenotype. Prior studies have observed abnormal hippocampal...
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Glucocorticoid Receptor Down-Regulation Affects Neural Stem Cell Proliferation and Hippocampal Neurogenesis
Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the glucocorticoid receptor (GR) have been linked to major depressive...
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Myosin Va-dependent Transport of NMDA Receptors in Hippocampal Neurons
N-methyl-D-aspartate receptor (NMDAR) trafficking is a key process in the regulation of synaptic efficacy and brain function. However, the molecular...
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Chronic unpredictable stress induces autophagic death of adult hippocampal neural stem cells
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and depression. Our previous...
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Volume changes of hippocampal and amygdala subfields in patients with mild cognitive impairment and Alzheimer’s disease
BackgroundAutomated segmentation of hippocampal and amygdala subfields could improve classification accuracy of Mild Cognitive Impairments (MCI) and...
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Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes
The hippocampus is critical for memory and cognition and neuropsychiatric disorders, and its subfields differ in architecture and function....
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TrkB-mediated neuroprotection in female hippocampal neurons is autonomous, estrogen receptor alpha-dependent, and eliminated by testosterone: a proposed model for sex differences in neonatal hippocampal neuronal injury
BackgroundNeonatal hypoxia ischemia (HI) related brain injury is one of the major causes of learning disabilities and memory deficits in children. In...
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Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation
Neuroinflammation contributes to the pathogenesis of depression. Inulin-type oligosaccharides of Morinda officinalis (IOMO) exert antidepressant-like...
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Changes in microstructural similarity of hippocampal subfield circuits in pathological cognitive aging
The hippocampal networks support multiple cognitive functions and may have biological roles and functions in pathological cognitive aging (PCA) and...
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Hippocampal Malrotation: Is It Epileptogenic?
Hippocampal malrotation (HIMAL) is an anatomical phenomenon appearing as incomplete rotation of the hippocampus in the course of ontogenesis. The...
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Heterotopic 4T1 breast cancer transplantation induces hippocampal inflammation and depressive-like behaviors in mice
Cancer and its accompanying treatments can lead to numerous physical and emotional concerns, including subclinical or clinical depression and...
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Transient global amnesia and hippocampal diffusion restriction: an overlooked radiological finding
Transient global amnesia (TGA) is characterized by isolated sudden anterograde amnesia. Diffusion restriction can be observed in the hippocampus on...
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Resistance Training Modulates Hippocampal Neuroinflammation and Protects Anxiety-Depression-like Dyad Induced by an Emotional Single Prolonged Stress Model
Stress is a triggering factor for anxious and depressive phenotypes. Exercise is known for its action on the central nervous system. This study aimed...
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Deferoxamine Mitigates Ferroptosis and Inflammation in Hippocampal Neurons After Subarachnoid Hemorrhage by Activating the Nrf2/TXNRD1 Axis
Ferroptosis is a distinct peroxidation-driven form of cell death tightly involved in subarachnoid hemorrhage (SAH). This study delved into the...
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Hippocampal subfield volumes in mild cognitive impairment and alzheimer’s disease: a systematic review and meta-analysis
The hippocampus is a complex structure that consists of several subfields with distinct and specialized functions. Although numerous studies have...
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Study of the human hippocampal formation: a method for histological and magnetic resonance correlation in perinatal cases
Little information is available on the magnetic resonance imaging (MRI) determination of the hippocampal formation (HF) during the perinatal period....
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The Chemokine CCL2 Promotes Excitatory Synaptic Transmission in Hippocampal Neurons via GluA1 Subunit Trafficking
The CC chemokine ligand 2 (CCL2, also known as MCP-1) and its cognate receptor CCR2 have well-characterized roles in chemotaxis. CCL2 has been...
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Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
BackgroundIn our previous study, we showed simvastatin exerts an antidepressant effect and inhibits neuroinflammation. Given the role of synaptic...
