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NORHA: A NORmal Hippocampal Asymmetry Deviation Index Based on One-Class Novelty Detection and 3D Shape Features
Radiologists routinely analyze hippocampal asymmetries in magnetic resonance (MR) images as a biomarker for neurodegenerative conditions like...
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The Role of the Dentate Gyrus in Mediating Hippocampal Functions: The Epileptic Brain
Temporal lobe epilepsy (TE) is characterized by loss of hippocampal cells, often leading to hippocampal sclerosis, subsequent reorganization of the...
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Profiling Analysis of Circular RNA and mRNA in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis ILAE Type 1
Hippocampal sclerosis (HS) is the most common surgical pathology associated with temporal lobe epilepsy (TLE). However, the cause of TLE with or...
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Selective vulnerability of hippocampal sub-regions in patients with subcortical vascular mild cognitive impairment
Early diagnosis of subcortical vascular mild cognitive impairment (svMCI) is clinically essential because it is the most reversible subtype of all...
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Mir155hg Accelerates Hippocampal Neuron Injury in Convulsive Status Epilepticus by Inhibiting Microglial Phagocytosis
Convulsive status epilepticus (CSE) is a common critical neurological condition that can lead to irreversible hippocampal neuron damage and cognitive...
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy
Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy....
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Roles of Adenosine Receptor (subtypes A1 and A2A) in Cuprizone-Induced Hippocampal Demyelination
Hippocampal demyelination in multiple sclerosis (MS) has been linked with cognitive deficits, however, patients could benefit from treatment that...
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Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis
The manifestations of tuberous sclerosis complex (TSC) in humans include epilepsy, autism spectrum disorders (ASD) and intellectual disability....
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Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow
BackgroundIn epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with...
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Simvastatin ameliorates synaptic plasticity impairment in chronic mild stress-induced depressed mice by modulating hippocampal NMDA receptor
BackgroundIn our previous study, we showed simvastatin exerts an antidepressant effect and inhibits neuroinflammation. Given the role of synaptic...
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Study of the human hippocampal formation: a method for histological and magnetic resonance correlation in perinatal cases
Little information is available on the magnetic resonance imaging (MRI) determination of the hippocampal formation (HF) during the perinatal period....
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CoQ10 targeted hippocampal ferroptosis in a status epilepticus rat model
Status epilepticus (SE), the most severe form of epilepsy, leads to brain damage. Uncertainty persists about the mechanisms that lead to the...
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Neurophysiological Aspects of Multiple Hippocampal Transection in Temporal Epilepsy
Objectives. To establish a correlation between intraoperative electrocorticography data and seizure monitoring after multiple hippocampal transection...
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Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
BackgroundIt is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier...
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Curcumin attenuates memory impairments and long-term potentiation deficits by damping hippocampal inflammatory cytokines in lipopolysaccharide-challenged rats
Neuroinflammation is a key pathological event triggering neurodegenerative process, resulting in neurologic sequelae. Curcumin (cur) has recently...
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Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats
To determine the dynamic effects of miR-20a-5p on hippocampal ripple energy in rats after status epilepticus (SE). A lithium pilocarpine...
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mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons
Plasticity of principal cells and inhibitory interneurons underlies hippocampal memory. Bidirectional modulation of somatostatin cell mTORC1...
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Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy
Epilepsy is a chronic brain disease that makes serious cognitive and motor retardation. Ion channels affect the occurrence of epilepsy in various...
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The Role of the Dentate Gyrus in Mediating Hippocampal Functions: The Healthy Brain
The dentate gyrus (DG), which is part of the hippocampal formation, is the main target of neocortical and subcortical afferents received by the...
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Nicorandil Exerts Anticonvulsant Effects in Pentylenetetrazol-Induced Seizures and Maximal-Electroshock-Induced Seizures by Downregulating Excitability in Hippocampal Pyramidal Neurons
N-(2-hydroxyethyl) nicotinamide nitrate (nicorandil), a nitrate that activates adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channels, is...
