Search
Search Results
-
Exercise and Muscle Glycogen Metabolism
Muscle glycogen is an important fuel source for contracting skeletal muscle, and it is well documented that exercise performance is impaired when the...
-
Optimization of PAS stain and similar Schiff’s based methods for glycogen demonstration in liver tissue
Demonstration of glycogen in tissue holds considerable diagnostic relevance across various pathological conditions, particularly in certain tumors....
-
Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
BackgroundHypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs),...
-
Standardization of Grocott’s methenamine (hexamine) silver method for glycogen demonstration in liver tissue
Demonstration of glycogen can be done in different lesions and is considered diagnostically significant, mainly in some tumors. Glycogen staining is...
-
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells
BackgroundExcessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 has the strongest...
-
Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats
Reproductive deficiency is a major outcome of pesticide exposure sequel to cellular oxidative damage to sex organs. Flavonoid possess potent...
-
Four-week experimental plus 1-week taper period using live high train low does not alter muscle glycogen content
This study aimed to investigate the effects of a 4-week live high train low (LHTL; FiO 2 ~ 13.5%), intervention, followed by a tapering phase, on...
-
Understanding Glycogen Synthase Kinase-3: A Novel Avenue for Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most prevalent form of age-related dementia. Even though a century has passed since the discovery of AD, the exact...
-
Carbohydrate intake before and during high intensity exercise with reduced muscle glycogen availability affects the speed of muscle reoxygenation and performance
Muscle glycogen state and carbohydrate (CHO) supplementation before and during exercise may impact responses to high-intensity interval training...
-
Sex Dimorphic Glucose Transporter-2 Regulation of Hypothalamic Astrocyte Glucose and Energy Sensor Expression and Glycogen Metabolism
The plasma membrane glucose transporter-2 (GLUT2) monitors brain cell uptake of the critical nutrient glucose, and functions within astrocytes of...
-
Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue
Parkinson’s disease (PD) is a progressive neurodegenerative disease of the brain due to degeneration of dopaminergic neurons in the substantia nigra...
-
A case study of a liver transplant-treated patient with glycogen storage disease type Ia presenting with multiple inflammatory hepatic adenomas: an analysis of clinicopathologic and genetic data
BackgroundGlycogen storage disease (GSD) is a disease caused by excessive deposition of glycogen in tissues due to genetic disorders in glycogen...
-
Broadening the Phenotype and Genotype Spectrum of Glycogen Storage Disease by Unraveling Novel Variants in an Iranian Patient Cohort
Glycogen storage diseases (GSDs) are a group of rare inherited metabolic disorders characterized by clinical, locus, and allele heterogeneity. This...
-
Glycogen as an Effective Target in Cancer Therapy
Research activities have presented different methods in cancer prevention, early detection, screening, diagnosis, and treatment. Furthermore, several...
-
A century of exercise physiology: key concepts in regulation of glycogen metabolism in skeletal muscle
Glycogen is a branched, glucose polymer and the storage form of glucose in cells. Glycogen has traditionally been viewed as a key substrate for...
-
Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice
Promotion of hepatic glycogen synthesis and inhibition of hepatic glucose production are effective strategies for controlling hyperglycemia in type 2...
-
Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation
Cellular immunity mediated by CD8 + T cells plays an indispensable role in bacterial and viral clearance and cancers. However, persistent antigen...
-
From common to rare: repurposing of bempedoic acid for the treatment of glycogen storage disease type 1
Hypoketotic hypoglycaemia is a biochemical hallmark of glycogen storage disease type 1 (GSD1). This is due to inhibition of carnitine-palmitoyl...
-
The expression of HSP70 in skeletal muscle is not associated with glycogen availability during recovery following prolonged exercise in elite endurance athletes
The 70-kDa heat shock protein (HSP70) is a ubiquitous molecular chaperone which is highly inducible by cellular stress such as exercise. To...
-
Increase of glycogen storage by sodium arsenite in rat cortical astrocytes through glycogen synthase activation and its association to toxicity
ObjectiveThe present study aimed primarily to evaluate the effect of sodium arsenite exposure on glucose metabolism includes glycogen accumulation on...
