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Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications
Glutathione (GSH) is an endogenous tripeptide (Glu-Cys-Gly) and the most abundant endogenous antioxidant. It protects the body against oxidative...
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Thioredoxin and Glutathione Systems
Most cancer cells contain high levels of reactive oxygen species (ROS), which result in higher expression levels of the glutathione and thioredoxin...
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Glutathione transporter as a target for brain drug delivery
Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the major cause of treatment...
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Fluorescence Quenching Effect of a Highly Active Nitroxyl Radical on 7-amino-4-methylcoumarin and Glutathione Sensing
Nitroxyl radical compounds, such as 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO), are stable radical compounds with a variety of unique...
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Glutathione Component of Antioxidant Status in Menopausal Women with Insomnia
The study involved 138 women aged 45-60 years in perimenopause ( n= 55) and postmenopause ( n= 83) with insomnia (main groups) and without it (control)....
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Heat Shock Protein HSP27 and the Status of the Glutathione System in Dexamethasone-Induced Apoptosis of Jurkat Tumor Cells
We studied the effect of the HSP27 inhibitor, 5-(5-ethyl-2-hydroxy-4-methoxyphenyl)-4-(4-methoxyphenyl)-isoxazole, at a final concentration of 0.1 μM...
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Parkin coregulates glutathione metabolism in adult mammalian brain
We recently discovered that the expression of PRKN , a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the...
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Glutathione conjugation of sesquimustard: in vitro investigation of potential biomarkers
Sesquimustard (Q) is a powerful blistering agent that contains additional sulfur atoms. Sulfur mustard causes covalent bonding by alkylating...
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Unveiling the Influence of Glutathione in Suppressing the Conversion of Aspirin to Salicylic Acid: A Fluorescence and DFT Study
Aspirin is a commonly used nonsteroidal anti-inflammatory drug, associated with many adverse effects. The adverse effects of aspirin such as...
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Picric Acid Incorporated Fluorescent Nitrogen Doped Carbon Dot for “Turn-On” Detection of Glutathione
Glutathione (GSH), a non-protein thiol in living cells whose abnormal level indicates the onset of diseases like Alzheimer’s, HIV, diabetes, cancer,...
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A Enhanced Fluorescent Probe for Simultaneous Detection and Discrimination of Hydrogen Bisulfite Anions and Glutathione
Bisulfite (HSO 3 − ) and biological thiols molecules, such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), play important roles in...
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Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma
Glaucoma is a leading cause of blindness worldwide in older people. Profiling the aqueous humor, including the metabolites it contains, is useful to...
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Glutathione as Oxidative Stress Marker in Cancer
In this review I describe the novel effect of glutathione (GSH) as an oxidative stress marker in cancer based on the recent research findings. Each...
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Glutathione Coating of Liposomes Enhances the Delivery of Hydrophilic Cargo to the Inner Nuclear Layer in Retinal Cultures
To successfully deliver intracellular compounds to retinal cells, a delivery system based on purified lipids, self-assembled into synthetic vesicles...
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The Effects of Modulators of the Coenzyme A Biosynthesis System on Metabolic Stress and the Glutathione System in the CNS in Aluminum Neurotoxicosis
Abstract —Alzheimer’s-like disease was simulated in female adult Wistar CRL(WI) WUBR rats by 6-week intragastric administration of aluminum chloride...
