Search
Search Results
-
The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer
Diabetes might be associated with increased cancer risk, with several studies reporting hyperglycemia as a primary oncogenic stimulant. Since glucose...
-
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of...
-
Hypoxia promotes metastasis by relieving miR-598-3p-restricted glycolysis in gastric cancer
The activation of glycolysis, particularly in the context of reprogrammed energy metabolism, is increasingly recognized as a significant...
-
RETRACTED ARTICLE: KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis
Our previous work showed that KRAS activation in gastric cancer cells leads to activation of an epithelial-to-mesenchymal transition (EMT) program...
-
Clinical implications of micro lymph node metastasis for patients with gastric cancer
BackgroundLymph node size is considered as a criterion for possible lymph node metastasis in imageology. Micro lymph nodes are easily overlooked by...
-
Cytoplasmic localization of IRF5 induces Wnt5a/E-cadherin degradation and promotes gastric cancer cells metastasis
IRF5, a nucleoplasm shuttling protein, is a pivotal transcription factor regulating immune system activity. It’s well known that immunosuppression is...
-
LINC00665 activating Wnt3a/β-catenin signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis
Long noncoding RNAs (lncRNAs) play a key role in human cancer development; nevertheless, the effect of lncRNA LINC00665 on the progression of gastric...
-
Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis
BackgroundPeritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable...
-
MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor
BackgroundThe Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a kinase and directly binding...
-
Identification and validation of crucial lnc-TRIM28-14 and hub genes promoting gastric cancer peritoneal metastasis
BackgroundGastric cancer peritoneal metastasis (GCPM) is an important cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) play a...
-
Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
BackgroundGastric Cancer (GC) presents poor outcome, which is consequence of the high incidence of recurrence and metastasis at early stages. GC...
-
System-wide identification of novel de-ubiquitination targets for USP10 in gastric cancer metastasis through multi-omics screening
ObjectiveUbiquitin-specific peptidase 10 (USP10), a typical de-ubiquitinase, has been found to play a double-edged role in human cancers. Previously,...
-
Synbiotics in Gastric Cancer
The growth of human gut microbiota is critical for, the metabolism and synthesis of short-chain fatty acids, nutrition absorption and vitamins,...
-
Myeloid-Derived Suppressor Cells and Cancer Metastasis
Myeloid-derived suppressor cells (MDSCs) are pathologically arisen cells mainly acknowledged for their role in immune suppression. Studies have...
-
RNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation
BackgroundMolecular analysis of advanced tumors can increase tumor heterogeneity and selection bias. We developed a robust prognostic signature for...
-
Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway
Gastric cancer (GC) is the most common malignant tumor of digestive system. Bufalin extracted from Venenum Bufonis is one of the most effective...
-
FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer
BackgroundFYN is a nonreceptor tyrosine kinase that regulates diverse pathological processes. The pro-cancer role of FYN in multiple malignancies has...
-
Tumor Associated Neutrophils (TANs) and Cancer Metastasis
Neutrophils play an important role in human innate immunity, but their role in cancer biology was underestimated. It was seen that a high...
-
Gastric Cancer: The Microbiome Beyond Helicobacter pylori
Gastric cancer remains an important global health burden. Helicobacter pylori is the major etiological factor in gastric cancer, infecting the...
-
A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc
BackgroundGastric cancer (GC) ranks fifth in global cancer incidence and third in mortality rate among all cancer types. Circular RNAs (circRNAs)...
