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Reducing Glut2 throughout the body does not result in cognitive behaviour differences in aged male mice
ObjectivesGLUT2 is a major facilitative glucose transporter, expressed from the SLC2A2 gene, with essential roles in the liver. Recent work in mice...
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Sex Dimorphic Glucose Transporter-2 Regulation of Hypothalamic Astrocyte Glucose and Energy Sensor Expression and Glycogen Metabolism
The plasma membrane glucose transporter-2 (GLUT2) monitors brain cell uptake of the critical nutrient glucose, and functions within astrocytes of...
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Effects of Three Kinds of Carbohydrate Pharmaceutical Excipients—Fructose, Lactose and Arabic Gum on Intestinal Absorption of Gastrodin through Glucose Transport Pathway in Rats
BackgroundSome glucoside drugs can be transported via intestinal glucose transporters (IGTs), and the presence of carbohydrate excipients in...
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Does Sertraline Affect Hypothalamic Food Intake Peptides in the Rat Experimental Model of Chronic Mild Stress-Induced Depression?
Depression is a chronic, recurrent and life-threatening disease affecting approximately 15% of the world population. Depression is responsible for...
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Promoting β-cells function by the recapitulation of in vivo microenvironmental differentiation signals
The study aims to transdifferentiate rat bone marrow–derived mesenchymal stem cells (BM-MSCs) more efficiently into islet-like cells and encapsulate...
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Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway
BackgroundDihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and...
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Antidiabetic potential of Chromolaena Odorata leave extract and its effect on Nrf2/keap1 antioxidant pathway in the liver of diabetic-induced Wistar Rats
The incidence of liver dysfunction increases in diabetes due to insulin resistance and oxidative stress. Chromolaena odorata is a dominant medicinal...
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O6-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms
BackgroundStreptozocin (STZ) is used for treating both pancreatic (PanNET) and gastrointestinal (GI-NET) neuroendocrine tumors but its therapeutic...
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Glucose transporters in the small intestine in health and disease
Absorption of monosaccharides is mainly mediated by Na + - d -glucose cotransporter SGLT1 and the facititative transporters GLUT2 and GLUT5. SGLT1 and...
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Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor controlling hepatocyte expression of numerous genes. Although expression changes...
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Alzheimer’s disease improved through the activity of mitochondrial chain complexes and their gene expression in rats by boswellic acid
The foremost neurodegenerative disease is Alzheimer’s (AD), which is characterized as a gradual decrease in memory, cognitive function, and also...
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Genomic Editing and Diabetes
The diabetes types and its complications have varying developmental and metabolic pathways. There is an interplay of nongenetic and genetic...
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Effects of Commonly used Surfactants, Poloxamer 188 and Tween 80, on the Drug Transport Capacity of Intestinal Glucose Transporters
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the...
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Nutrient sensors and their crosstalk
The macronutrients glucose, lipids, and amino acids are the major components that maintain life. The ability of cells to sense and respond to...
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Nutrition and Common Diseases
In this chapter, we will provide a first overview of the role of nutrition on our health and risk for disease. During the past 50 years a significant...
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Impact of an SGLT2-loss of function mutation on renal architecture, histology, and glucose homeostasis
Inhibitors of sodium/glucose co-transporter 2 (SGLT2) are currently in clinical use for type 2 diabetes (T2D) treatment due to their...
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Non-Aquaporin Water Channels
Water transport through membrane is so intricate that there are still some debates. AQPs are entirely accepted to allow water transmembrane movement...
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Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease
A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific glucose uptake and metabolism in the liver, skeletal...
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Glucose transporters in pancreatic islets
The fine-tuning of glucose uptake mechanisms is rendered by various glucose transporters with distinct transport characteristics. In the pancreatic...
