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Global prevalence of organohalide-respiring bacteria dechlorinating polychlorinated biphenyls in sewage sludge
BackgroundMassive amounts of sewage sludge are generated during biological sewage treatment and are commonly subjected to anaerobic digestion, land...
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Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models
BackgroundDiffuse-type gastric cancer (DGC) exhibits rapid disease progression and poor patient prognosis. We have previously established an...
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A metagenomics roadmap to the uncultured genome diversity in hypersaline soda lake sediments
BackgroundHypersaline soda lakes are characterized by extreme high soluble carbonate alkalinity. Despite the high pH and salt content, highly diverse...
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Community genomic analyses constrain the distribution of metabolic traits across the Chloroflexi phylum and indicate roles in sediment carbon cycling
BackgroundSediments are massive reservoirs of carbon compounds and host a large fraction of microbial life. Microorganisms within terrestrial aquifer...
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Synthesis and Biological Activity of Cholecystokinin Antagonists
Cholecystokinin (CCK) is a gastrointestinal hormone1 that stimulates satiety2 and pancreatic enzyme secretions in digestion. The active portion of...