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GABA Pathways and Receptors
GABAergic neurons including Purkinje cells play critical roles in cerebellar neuronal circuits. In the cerebellar cortex, molecular layer...
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Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA
BackgroundThe γ-aminobutyric acid (GABA) hypothesis posits a role of GABA deficiency in the central nervous system in the pathogenesis and...
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GABA tone regulation and its cognitive functions in the brain
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at GABAergic synapses, mediating fast-acting phasic inhibition. Emerging...
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The Role of Extrasynaptic GABA Receptors in Postpartum Depression
Postpartum depression is a serious disease with a high incidence and severe impact on pregnant women and infants, but its mechanism remains unclear....
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Tonic excitation by astrocytic GABA causes neuropathic pain by augmenting neuronal activity and glucose metabolism
Neuropathic pain is a debilitating condition caused by the hyperexcitability of spinal dorsal horn neurons and is often characterized by allodynia....
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Structure-function Studies of GABA (A) Receptors and Related computer-aided Studies
The γ-aminobutyric acid type A receptor (GABA (A) receptor) is a membrane protein activated by the neurotransmitter GABA. Structurally, this major...
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GABA Receptor SNPs and Elevated Plasma GABA Levels Affect the Severity of the Indian ASD Probands
Altered signaling of the chief inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), has been speculated in the etiology of autism spectrum...
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Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity
The external globus pallidus (GP) firing rate synchronizes the basal ganglia-thalamus-cortex network controlling GABAergic output to different...
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GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells
Two coordinated dynamic properties (adaptation and sensitization) are observed in retinal ganglion cells (RGCs) under the contrast stimulation....
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Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS
Polycystic ovarian syndrome (PCOS) is a known endocrine disorder that has affected many women of childbearing age, and is accompanied by various...
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Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation
ObjectivesOur previous clinical trial showed that etomidate requirements to reach an appropriate level of anesthesia in patients with obstructive...
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Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models
Epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients are resistant to existing medications. It is of utmost...
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14-3-3ζ Mediates GABAAR Activation by Interacting with BIG1
Most fast synaptic inhibitions in the mammalian brain are mediated by GABA A receptors (GABA A Rs). An appropriate level of GABA A R expression at the...
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Attenuation of Streptozotocin-Induced Diabetic Neuropathic Allodynia by Flavone Derivative Through Modulation of GABA-ergic Mechanisms and Endogenous Biomarkers
Diabetic neuropathic pain is one of the most devasting disorders of peripheral nervous system. The loss of GABAergic inhibition is associated with...
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GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway
BackgroundResearch has indicated that long-term sleep deprivation can lead to immune dysfunction and participate in the occurance and progression of...
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The Role of Neurotransmitters in Epileptogenesis: Focus on GABA and Glutamate
Epileptic seizures are frequently referred to as a brief development of a number of signs and symptoms resulting from extreme or synchronized...
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NLRP3–GABA signaling pathway contributes to the pathogenesis of impulsive-like behaviors and cognitive deficits in aged mice
BackgroundPerioperative neurocognitive disorders (PND), such as delirium and cognitive impairment, are commonly encountered complications in aged...
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Salifen Prevents Perinatal Hypoxia-Induced Cognitive Impairments and Changes in the Expression of GABAB Receptors in the Rat Neocortex
We report here a study examining the effects of acute normobaric hypoxia in the early postnatal period of development (postnatal day 2) on learning...
