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Neuroimaging of Fear Extinction
Extinguishing fear and defensive responses to environmental threats when they are no longer warranted is a critical learning ability that can promote...
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Fear Extinction From Basic Neuroscience to Clinical Implications
This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring...
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Enhancing Fear Extinction: Pharmacological Approaches
Extinction is the process by which the memory of a learned conditioned association decreases over time and with introduction of new associations. It...
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Reconsolidation and Fear Extinction: An Update
Fear memories can be updated behaviorally by delivering extinction trials during the reconsolidation window, which results in a persistent...
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Fear Extinction as a Psychologist Views It
Fear extinction is a topic of central importance in translational neuroscience. It integrates knowledge from various disciplines, including clinical...
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Memory Trace for Fear Extinction: Fragile yet Reinforceable
Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement, allowing the organism to...
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Fear Extinction Learning in Posttraumatic Stress Disorder
Impairments in fear extinction processes have been implicated in the genesis and maintenance of debilitating psychopathologies, including...
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Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
Acquisition and extinction of associative fear memories are critical for guiding adaptive behavioral responses to environmental threats, and...
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Is Fear Extinction Impairment Central to Psychopathology?
As discussed in this chapter, there have been enormous advances in our understanding of how anxiety disorders develop, are maintained, and can be...
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Extinction-Based Exposure Therapies Using Virtual Reality
The focus of this chapter is an overview of integrating virtual reality (VR) technology within the context of exposure therapy for anxiety disorders,...
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The Impact of Sleep on Fear Extinction
Sleep plays a crucial role in the consolidation of memories, including those for fear acquisition and extinction training. This chapter reviews...
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Deep-learning-enabled antibiotic discovery through molecular de-extinction
Molecular de-extinction aims at resurrecting molecules to solve antibiotic resistance and other present-day biological and biomedical problems. Here...
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Understanding Human Fear Extinction: Insights from Psychophysiology
The study of fear extinction has been driven largely by Pavlovian fear conditioning methods across the translational spectrum. The primary methods...
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Impact of Stress and Exercise on Fear Extinction
This chapter reviews the literature on the impact of stress and exercise on fear extinction. Given that key brain regions of the fear circuitry...
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Involvement of dysregulated hippocampal histone H3K9 methylation at the promoter of the BDNF gene in impaired memory extinction
RationaleSince the precise mechanisms of posttraumatic stress disorder (PTSD) remain unknown, effective treatment interventions have not yet been...
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Stress Immobilization Inducing Fear Extinction Deficits in Male and Female Mice
Fear extinction alterations are a core symptom of post-traumatic stress disorder(PTSD). Traditionally, animal models of fear extinction mainly use...
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Conflict Dynamics of Post-Retrieval Extinction: A Comparative Analysis of Unconditional and Conditional Reminders Using Skin Conductance Responses and EEG
The post-retrieval extinction paradigm, rooted in reconsolidation theory, holds promise for enhancing extinction learning and addressing anxiety and...
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Keratinocyte-Derived Cytokine in the Hippocampus Disrupts Extinction of Conditioned Fear Memory in Tumor-Bearing Mice
While patients with cancer show a higher prevalence of psychiatric disorders than the general population, the mechanism underlying this interaction...
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Effects of cannabidiol on fear conditioning in anxiety disorders: decreased threat expectation during retention, but no enhanced fear re-extinction
RationalePreclinical research suggests that pharmacologically elevating cannabinoid levels may attenuate fear memory expression and enhance fear...
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Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice
Adenylyl cyclase 1 (AC1) is a selective subtype of ACs, which is selectively expressed in neurons. The activation of AC1 is activity-dependent, and...
