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USP14 Regulates ATF2/PIK3CD Axis to Promote Microvascular Endothelial Cell Proliferation, Migration, and Angiogenesis in Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the leading causes of blindness in diabetic patients. However, the pathogenesis of DR is complex, and no firm...
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Effect of somatic antigens of Dirofilaria repens adult worms on angiogenesis, cell proliferation and migration and pseudo-capillary formation in human endothelial cells
BackgroundAngiogenesis is defined as the formation of new vessels by sprouting of endothelial cells from pre-existing vessels in response to stimuli,...
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Senescent endothelial cells promote liver metastasis of uveal melanoma in single-cell resolution
BackgroundUveal melanoma (UM), the most common adult intraocular tumor, is characterized by high malignancy and poor prognosis in advanced stages....
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Flow goes forward and cells step backward: endothelial migration
Systemic and pulmonary circulations constitute a complex organ that serves multiple important biological functions. Consequently, any pathological...
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MiR-15p-5p Mediates the Coordination of ICAM-1 and FAK to Promote Endothelial Cell Proliferation and Migration
Intercellular adhesion molecule-1 (ICAM-1) in endothelial cells is critical for neutrophil adhesion and transmigration across the endothelium. Focal...
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Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis
Lymphangiogenesis is an essential physiological process but also a determining factor in vascular-related pathological conditions. Angiopoietin-2...
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Circular RNAs: Regulators of endothelial cell dysfunction in atherosclerosis
Endothelial cell (EC) dysfunction is associated with atherosclerosis. Circular RNAs (circRNAs) are covalently closed loops formed by back-splicing,...
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pH-regulated single cell migration
Over the last two decades, extra- and intracellular pH have emerged as fundamental regulators of cell motility. Fundamental physiological and...
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CD93 a potential player in cytotrophoblast and endothelial cell migration
CD93, also known as complement component C1q receptor, is expressed on the surface of different cellular types such as monocytes, neutrophils,...
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Downregulated calmodulin expression contributes to endothelial cell impairment in diabetes
Endothelial dysfunction, a central hallmark of cardiovascular pathogenesis in diabetes mellitus, is characterized by impaired endothelial nitric...
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Neutrophil trogocytosis during their trans-endothelial migration: role of extracellular CIRP
BackgroundNeutrophils are the most abundant innate immune cells in the circulating blood, and they act as the first responder against bacterial and...
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Human Umbilical Cord Mesenchymal Stem Cells Repair Endothelial Injury and Dysfunction by Regulating NLRP3 to Inhibit Endothelial Cell Pyroptosis in Kawasaki Disease
Vascular endothelial inflammation and endothelial dysfunction are the main causes of endothelial injury in Kawasaki disease (KD). Human umbilical...
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Anti-Vascular Endothelial Growth Factor Therapy Abolishes Glioma-Associated Endothelial Cell-Induced Tumor Invasion
Tumor-remodeled endothelial cells not only facilitate the formation of tumor angiogenesis but also promote tumorigenesis. In this study, we aimed to...
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Gradient Biomaterials and Their Impact on Cell Migration
Cell migration participates in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel...
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Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood − brain barrier function
Autoreactive T lymphocytes crossing the blood-brain barrier (BBB) into the central nervous system (CNS) play a crucial role in the initiation of...
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Understanding tumour endothelial cell heterogeneity and function from single-cell omics
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their success is limited owing to insufficient efficacy and...
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Determination of Endothelial Barrier Resistance by Electric Cell-Substrate Impedance Sensing (ECIS) System
Endothelial cells lining the inner surface of blood vessels and lymphatic vessels play an indispensable role in vascular homeostasis. Apart from...
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CircRNA7632 down-regulation alleviates endothelial cell dysfunction in Kawasaki disease via regulating IL-33 expression
Kawasaki disease (KD) is a form of idiopathic vasculitis frequently accompanied by coronary artery lesions, which involves endothelial dysfunction....
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Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway
BackgroundExosome is crucial mediator and play an important role in tumor angiogenesis. Tip cell formation is a prerequisite for persistent tumor...
