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The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act
RationaleLemborexant (LEM) is a dual orexin receptor antagonist (DORA) approved in multiple countries including the USA, Japan, Canada, Australia,...
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Effects of TS-142, a novel dual orexin receptor antagonist, on sleep in patients with insomnia: a randomized, double-blind, placebo-controlled phase 2 study
RationaleNovel compound with potent antagonistic activity against orexin receptors may be new treatment option for patients with insomnia.
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Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia
Dual orexin receptor antagonists (DORAs) represent a novel type of sleep medication that provide an alternative to the traditionally used positive...
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Correction to: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence
The title of this article is “Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to...
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Melanin-concentrating hormone and orexin shape social affective behavior via action in the insular cortex of rat
RationaleIn a social context, individuals are able to detect external information from others and coordinate behavioral responses according to the...
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Control and coding of pupil size by hypothalamic orexin neurons
Brain orexin (hypocretin) neurons are implicated in sleep–wake switching and reward-seeking but their roles in rapid arousal dynamics and reward...
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Discovery of New Transmitter Systems and Hence New Drug Targets
The development of medicationsMedications used to treat psychiatric conditions has largely proceeded through serendipity, where a potential drug to...
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Lemborexant as a Potential Risk Factor for Sleep-Related Bruxism in a Patient with Complex Post-traumatic Stress Disorder: A Case Report
This article describes a case involving a 21-year-old woman with complex post-traumatic stress disorder (C-PTSD) who developed sleep-related bruxism...
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Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens
Orexin neurons are involved in homeostatic regulatory processes, including arousal and feeding, and provide a major input from the hypothalamus to...
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Daridorexant for the treatment of insomnia disorder: findings and implications
PurposeThe involvement of the orexin system in the physiopathology of insomnia has been rapidly increasing in understanding. In this sense,...
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PSPH-D-18-00526: Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence
RationaleSleep difficulties are one of the problems associated with adolescent binge drinking. However, the mechanisms underlying adolescent...
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Inhibition of Orexin-1/2 Receptors Disrupts Goal-Oriented Locomotor Activity During Motivated Behaviour in Male Rats
PurposeOrexinergic neurons in the lateral hypothalamic area project to the major wake-promoting areas of the brain and regulate many behavioural...
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Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
RationaleThe female menstrual or estrous cycle and its associated fluctuations in circulating estradiol (E2), progesterone, and other gonadal...
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Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders
Orexins comprise two neuropeptides produced by orexin neurons in the lateral hypothalamus and are released by extensive projections of these neurons...
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Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala
Primarily regarded as immune proteins, chemokines are emerging as a family of molecules serving neuromodulatory functions in the developing and adult...
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Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling
Accumulating evidence suggest that ghrelin plays a role as an antiseptic peptide. The present study aimed to clarify whether the brain may be...
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Correction to: Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist
The article Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist, written by Mariko So,...
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Differential Roles of Intra-accumbal Orexin Receptors in Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference in the Rats
A large amount of document has revealed that the orexin system in the reward circuity, including the nucleus accumbens (NAc), contributes to the...
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Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice
Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have various negative effects on patients, their families and...
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Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation
RationaleSamelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral...
