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Drugs of Abuse: Trends and Advanced Analytical Methods
Abuse of drugs is correlated with various medical, behavioral, psychological, spiritual, financial, social, family, and legal concerns and profoundly...
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Abuse of Performance-Enhancing Drugs
Anabolic-androgen steroids (AASs) are the primary drug class in a larger pattern of drug use designed to improve one’s appearance or alter their...
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Influence of Sex on the Effects of Nicotine and Other Drugs of Abuse on Intracranial Self-Stimulation
Drug abuse is one of the leading causes of loss of productivity, disease, and early death in the world. People typically start experimenting with...
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A Chewing Study of Abuse-Deterrent Tablets Containing Polyethylene Oxide Using a Robotic Simulator
Abuse-deterrent formulations (ADFs) refer to formulation technologies aiming to deter the abuse of prescription drugs by making the dosage forms...
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Drugs of Abuse Affecting 5-HT2B Receptors
Stimulant and psychedelic drugs of abuse exert their effects through interactions with monoaminergic systems. Compared to other monoaminergic...
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Effect of Stanozolol and/or Cannabis Abuse on Hypertrophic Mechanism and Oxidative Stress of Male Albino Rat Cardiac Tissue in Relation to Exercise: A Sport Abuse Practice
Adolescents commonly co-abuse many drugs including anabolic androgenic steroids either they are athletes or non-athletes. Stanozolol is the major...
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The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act
RationaleLemborexant (LEM) is a dual orexin receptor antagonist (DORA) approved in multiple countries including the USA, Japan, Canada, Australia,...
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Opioid abuse and SIV infection in non-human primates
Human immunodeficiency virus (HIV) and drug abuse are intertwined epidemics, leading to compromised adherence to combined antiretroviral therapy...
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Influence of Social Defeat Stress on the Rewarding Effects of Drugs of Abuse
Drug addiction is a serious problem in our society. Some individuals develop dependence to different substances very accessible in the market, mainly...
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Substance abuse and neurodegenerative diseases: focus on ferroptosis
Psychostimulants and alcohol are widely abused substances with the adverse effects on global public health. Substance abuse seriously harms people's...
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Design of Abuse-Deterrent Formulations Using Various Types of Thermal Deformed Starch (TDS)
PurposeIn recent years, the problem of drug abuse has emerged and is becoming more serious. Drug abuse can be secretly and illegally perpetuated by...
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Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Sudden death could occur after assumption of illicit drugs for recreational purposes in adults or after intoxication in children, and toxicological...
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The imidazoline I2 receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination
RationaleIncreasing evidence shows that imidazoline I 2 receptor agonists enhance opioid-induced analgesia, suggesting that the combination of I 2 ...
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A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential ‘culprit’ for the tramadol ‘abuse crisis’
BackgroundCytochrome P450 2D6 is involved in the metabolism of several important medicines including opioids. Variations in CYP2D6 have been...
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Abuse and dependence potential of sphingosine-1-phosphate (S1P) receptor modulators used in the treatment of multiple sclerosis: a review of literature and public data
Abuse and misuse of prescription drugs remains an ongoing concern in the USA and worldwide; thus, all centrally active new drugs must be assessed for...
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Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe
PurposeFentanyl, a highly potent synthetic opioid used in cancer and non-cancer pain, is approved for various routes of administration. In Europe,...
