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The imidazoline I2 receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination
RationaleIncreasing evidence shows that imidazoline I 2 receptor agonists enhance opioid-induced analgesia, suggesting that the combination of I 2 ...
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Reinstatement of nicotine conditioned place preference in a transgenerational model of drug abuse vulnerability in psychosis: Impact of BDNF on the saliency of drug associations
RationalePsychotic disorders such as schizophrenia are often accompanied by high rates of cigarette smoking, reduced quit success, and high relapse...
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Opioid abuse and SIV infection in non-human primates
Human immunodeficiency virus (HIV) and drug abuse are intertwined epidemics, leading to compromised adherence to combined antiretroviral therapy...
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Drug Addiction and Drug Dependency
Drug abuse and dependency liability assessments are important components of the discovery, development, and evaluation of novel drug entities and are...
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Design of Abuse-Deterrent Formulations Using Various Types of Thermal Deformed Starch (TDS)
PurposeIn recent years, the problem of drug abuse has emerged and is becoming more serious. Drug abuse can be secretly and illegally perpetuated by...
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Drugs of Abuse: Trends and Advanced Analytical Methods
Abuse of drugs is correlated with various medical, behavioral, psychological, spiritual, financial, social, family, and legal concerns and profoundly...
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Effect of Stanozolol and/or Cannabis Abuse on Hypertrophic Mechanism and Oxidative Stress of Male Albino Rat Cardiac Tissue in Relation to Exercise: A Sport Abuse Practice
Adolescents commonly co-abuse many drugs including anabolic androgenic steroids either they are athletes or non-athletes. Stanozolol is the major...
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Substance abuse and neurodegenerative diseases: focus on ferroptosis
Psychostimulants and alcohol are widely abused substances with the adverse effects on global public health. Substance abuse seriously harms people's...
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Health effects associated with exposure to intimate partner violence against women and childhood sexual abuse: a Burden of Proof study
The health impacts of intimate partner violence against women and childhood sexual abuse are not fully understood. Here we conducted a systematic...
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The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act
RationaleLemborexant (LEM) is a dual orexin receptor antagonist (DORA) approved in multiple countries including the USA, Japan, Canada, Australia,...
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A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential ‘culprit’ for the tramadol ‘abuse crisis’
BackgroundCytochrome P450 2D6 is involved in the metabolism of several important medicines including opioids. Variations in CYP2D6 have been...
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Environmental Enrichment and the Effects on Drug Abuse Vulnerability: The Last Ten Years
Environmental enrichment in rats during development has been shown to reliably alter the sensitivity to various drugs of abuse. The current chapter...
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In vitro studies on the dependence of drug deposition in dentin on drug concentration, contact time, and the physicochemical properties of the drugs
The chemical analysis of dental hard tissues can provide information on previous drug use due to the deposition of drugs into this tissue. For the...
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Extracellular Vesicles in HIV, Drug Abuse, and Drug Delivery
Extracellular vesicles (EVs) are known to perform important biological functions and have been implicated in multiple disease pathogeneses, including...
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A Chewing Study of Abuse-Deterrent Tablets Containing Polyethylene Oxide Using a Robotic Simulator
Abuse-deterrent formulations (ADFs) refer to formulation technologies aiming to deter the abuse of prescription drugs by making the dosage forms...
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Drug Dependence and Abuse
Physical dependence and addiction differ in that addiction causes activation of certain dopaminergic pathways in the mesolimbic system. Addiction...
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Drug Development for New Psychiatric Drug Therapies
Drug development is an expensive, high risk, and highly regulated process. Only about 6.2% of new molecules tested for mental disorders eventually...
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Cannabinoids Pharmacology, Abuse, and Addiction
Cannabis has a long history of therapeutic use and misuse. Δ-9-tetrahydrocannabinol (THC) was identified as the principle psychoactive component of...
