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Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence
BackgroundClinical and preclinical research have demonstrated that short-term exposure to nicotine during the initial experimentation stage can lead...
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Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence
Alcohol dependence is a disorder with a high recurrence rate that leads to a considerable public health burden. The risk of relapse appears to be...
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Anhedonia in Nicotine Dependence
Prior findings indicate that trait anhedonia enhances the likelihood of becoming a tobacco smoker, and preliminary evidence suggests that smoking...
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Abuse and dependence potential of sphingosine-1-phosphate (S1P) receptor modulators used in the treatment of multiple sclerosis: a review of literature and public data
Abuse and misuse of prescription drugs remains an ongoing concern in the USA and worldwide; thus, all centrally active new drugs must be assessed for...
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Features of Decision-Making in Patients with Alcohol Dependence
Objectives . To identify electroencephalographic correlates of decision-making features in patients with alcohol dependence. Materials and methods ....
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Physiological dependence to mitragynine indicated by a rapid cross-dependence procedure with heroin-dependent mice
The potential of mitragynine to produce physiological dependence (withdrawal) was assessed using a rapid assessment procedure with male ICR mice...
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Fierce poison to others: the phenomenon of bacterial dependence on antibiotics
Beyond the development of resistance, the effects of antibiotics on bacteria and microbial communities are complex and far from exhaustively studied....
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Opioid Dependence, Tolerance, and Withdrawal
This chapter describes the main adaptive changes occurring after repeated opioid administration at different levels: behavioral, pharmacological,...
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Altered individual gray matter structural covariance networks in early abstinence patients with alcohol dependence
While alterations in cortical thickness have been widely observed in individuals with alcohol dependence, knowledge about cortical thickness-based...
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Impairments to the Cognitive Mechanisms of Reward-Associated Decision-Making in Alcohol Dependence
Objectives. To evaluate the associations between impairments in reward-based cognitive decision-making mechanisms and clinical indicators of alcohol...
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Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts
Substance use disorders present similar behaviors and psychopathologies related to impaired decision making/inhibition control and information...
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Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
Morphine (MPH) is widely used for pain management; however, long-term MPH therapy results in antinociceptive tolerance and physical dependence,...
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The Role of Nicotine Metabolic Rate on Nicotine Dependence and Rewarding: Nicotine Metabolism in Chinese Male Smokers and Male Mice
The exact relationship between nicotine metabolism and dependence is not fully understood but is known to be influenced at a molecular level by...
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Eccentric exercise-induced muscle weakness amplifies the history dependence of force
IntroductionFollowing active lengthening or shortening contractions, isometric steady-state torque is increased (residual force enhancement; rFE) or...
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The Dependence of the Electrophysiological Effects of Class III Antiarrhythmic Drug Refralon on the Frequency of Myocardium Activation
We studied the frequency dependence of the effects of the novel Russian class III antiarrhythmic drug refralon on the duration of action potentials...
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Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe
PurposeFentanyl, a highly potent synthetic opioid used in cancer and non-cancer pain, is approved for various routes of administration. In Europe,...
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Energy dependence of synchronization mode transitions in the delay-coupled FitzHugh-Nagumo system driven by chaotic activity
Energy absorption and consumption are essential for the activity of single neurons and neuronal networks. The synchronization mode transition and...
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Loudness Dependence of Auditory Evoked Potentials: A Promising Pre-treatment Predictor of Selective Serotonin Reuptake Inhibitor Response
Selective serotonin reuptake inhibitors are the most commonly prescribed class of medications for patients with PTSD. However, many patients are not...
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The electrical restitution of the non-propagated cardiac ventricular action potential
Sudden changes in pacing cycle length are frequently associated with repolarization abnormalities initiating cardiac arrhythmias, and physiologists...
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Generative models for age, race/ethnicity, and disease state dependence of physiological determinants of drug dosing
Dosing requires consideration of diverse patient-specific factors affecting drug pharmacokinetics and pharmacodynamics. The available pharmacometric...
