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Chronic Coronary Artery Disease
Atherosclerosis is a chronic arterial disease and represents the first leading cause of vascular disease worldwide [1]. In addition, forecast...
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Extracellular Vesicles in Coronary Artery Disease
Coronary artery disease (CAD) is the leading cause of death and disability worldwide. Despite recent progress in the diagnosis and treatment of CAD,...
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Clinical Presentation and Therapy of Coronary Artery Anomalies
There are two major coronary arteries that arise normally directly above the aortic valve in the sinus. The left main coronary artery (LCA or LMCA)...
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Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease
BackgroundRecent studies suggest that classical coronary risk factors play a significant role in the pathogenesis of coronary artery disease. Our...
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Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki disease
Kawasaki disease (KD) is a multisystem inflammatory illness of infants and young children that can result in acute vasculitis. The mechanism of...
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miR194 hypomethylation regulates coronary artery disease pathogenesis
Coronary artery disease (CAD) is one of the most common heart diseases, characterized by the hardening and narrowing of arteries, resisting blood...
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Predicting the presence of coronary plaques featuring high-risk characteristics using polygenic risk scores and targeted proteomics in patients with suspected coronary artery disease
BackgroundThe presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the...
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A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before onset—remains an important public health need. Prior...
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The Increased TIGIT-Expressing CD3+CD56+ Cells Are Associated with Coronary Artery Disease and Its Inflammatory Environment
We aimed to examine the correlation of T-cell immunoglobulin and ITIM domain (TIGIT)-expressing CD3 + CD56 + cells (TNKS) with coronary artery...
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Outcomes of patients with COVID-19 and coronary artery disease and heart failure: findings from the Philippine CORONA study
BackgroundPatients with coronavirus disease 2019 (COVID-19) and coronary artery disease (CAD) or heart failure (HF) are more likely to have poor...
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Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease
BackgroundCoronary artery calcification (CAC) is a highly specific marker of atherosclerosis. Niemann-Pick C1-like 1 (NPC1L1) and...
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Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease
Coronary artery disease (CAD) exists on a spectrum of disease represented by a combination of risk factors and pathogenic processes. An in silico...
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Introducing Circulating Vasculature-Related Transcripts as Biomarkers in Coronary Artery Disease
BackgroundAtherosclerotic plaque is considered the hallmark of atherosclerotic lesions in coronary atherosclerosis (CAS), the primary pathogenesis in...
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Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic influences across cell types. Genome-wide association studies have...
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Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection
Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that...
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Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation
Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what...
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Coronary Artery Disease Detected by Low Frequency Heart Sounds
ObjectivesPrevious studies have observed an increase in low frequency diastolic heart sounds in patients with coronary artery disease (CAD). The aim...
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Endothelin-converting Enzyme-1b Genetic Variants Increase the Risk of Coronary Artery Ectasia
Coronary artery ectasia (CAE), defined as a 1.5-fold or greater enlargement of a coronary artery segment compared to the adjacent normal coronary...
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Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted...
