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The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act
RationaleLemborexant (LEM) is a dual orexin receptor antagonist (DORA) approved in multiple countries including the USA, Japan, Canada, Australia,...
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On the Edges: The Ethics of Human Studies with Psychedelic Substances
Classical psychedelics or hallucinogens, such as mescaline, psilocybin, dimethyltryptamine, and salvia, have been used in religious, shamanic, and...
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Utility of in vivo metabolomics to support read-across for UVCB substances under REACH
Structure-based grouping of chemicals for targeted testing and read-across is an efficient way to reduce resources and animal usage. For substances...
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Biomaterials for Controlled Drug Delivery Applications
A drug delivery system (DDS) is by definition a platform that can transfer a therapeutic agent to the disease site in order to elicit and improve the...
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Cyanobacterial Extracellular Polymeric Substances (EPS)
Cyanobacteria are a very particular group of photoautotrophic prokaryotic organisms with major ecological significance in the carbon and nitrogen...
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Synthetic Opioids as New Psychoactive Substances (NPS)
The last decade has seen a significant increase in synthetic opioids among the new psychoactive substances (NSP). The first two sections of this...
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The wound healing effect of botanicals and pure natural substances used in in vivo models
Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the...
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Alpha- and beta-pinene isomers act differently to control Rhipicephalus microplus (Acari: Ixodidae)
The cattle tick Rhipicephalus microplus is an ectoparasite of high importance in veterinary medicine and public health. Since synthetic chemicals...
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Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors
Assessment factors (AFs) are essential in the derivation of occupational exposure limits (OELs) and indoor air quality guidelines. The factors shall...
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Per- and Polyfluoroalkyl Substances (PFAS) and Their Toxicology as Evidenced Through Disease and Biomarkers
Per- and polyfluoroalkyl substances (PFAS) are a group of at least 4730 chemicals with clearly important surfactant properties. They are used in...
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Scheduling synthetic cathinone substances under the Controlled Substances Act
Background and rationaleCathinones are amphetamine analogues that produce stimulant effects with rewarding properties. For many decades, synthetic...
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An Integrative QbD Approach for the Development and Optimization of Controlled Release Compressed Coated Formulation of Water-Soluble Drugs
Controlled release dosage forms maintain regulated pharmacokinetic profile of drug substance within its therapeutic window by ensuring constant...
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Types of Polymeric Micelles for Controlled Drug Release
Polymeric micelles are nano-sized drug delivery carrier systems with a core or shell structure composed of biocompatible and biodegradable...
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Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum
BackgroundCurrently, society and industry generate huge amounts of plastics worldwide. The ubiquity of microplastics is obvious, but its impact on...
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Developments in high-resolution mass spectrometric analyses of new psychoactive substances
The proliferation of new psychoactive substances (NPS) has necessitated the development and improvement of current practices for the detection and...
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Cyanobacterial Extracellular Polymeric Substances (EPS)
Cyanobacteria are a very particular group of photoautotrophic prokaryotic organisms with major ecological significance in the carbon and nitrogen...
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Biological role and expression of translationally controlled tumor protein (TCTP) in tumorigenesis and development and its potential for targeted tumor therapy
Translationally controlled tumor protein (TCTP), also known as histamine-releasing factor (HRF) or fortilin, is a highly conserved protein found in...
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Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment
Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions....
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Forensic Drug Chemistry: Unravelling Evidence Through Scientific Analysis
Forensic drug chemistry plays a pivotal role in modern criminal investigations by utilising scientific methods to identify, analyse, and interpret...
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Cognitive-Enhancing Substances and the Developing Brain: Risks and Benefits
Growing competitiveness in education and workplaces has led to increased interest in cognitive-enhancing substances. Abuse of prescription drugs...
