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Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse
RationaleThere are no FDA-approved treatments to facilitate recovery from cocaine use disorder. Contingency management offers non-drug reinforcers to...
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Cocaine as a Neurotoxin
Cocaine is a widely abused psychostimulant drug, with sympathomimetic properties and intense euphoric effects. Cocaine and some of its toxic...
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Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking
RationaleCocaine can increase inflammatory neuroimmune markers, including chemokines and cytokines characteristic of innate inflammatory responding....
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Neurotoxicity of crack cocaine exposure: evidence from a systematic review of in vitro and in vivo studies
Several studies suggest that crack cocaine users exhibit higher prevalence of both psychiatric and psychosocial problems, with an aggressive pattern...
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Renewal of cocaine seeking using social and nonsocial contextual stimuli
RationaleVarious nonsocial cues have been used as stimuli to examine the contextual control of drug seeking behavior, but little is known about the...
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Suppression of HIV-TAT and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters
HIV-associated neurological disorder (HAND) is a serious complication of HIV infection marked by neurotoxicity induced by viral proteins like Tat....
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The positive reinforcing effects of cocaine and opposite-sex social contact: roles of biological sex and estrus
RationalePreclinical studies report that drug use and social contact mutually influence the reinforcing effects of one another. Most of these studies...
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Acute, but not repeated, cocaine exposure alters allopregnanolone levels in the midbrain of male and female rats
RationaleMultiple psychiatric disorders are associated with altered brain and serum levels of neuroactive steroids, including the endogenous...
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Acquisition of cocaine reinforcement using fixed-ratio and concurrent choice schedules in socially housed female and male monkeys
RationalePrevious studies in socially housed monkeys examining acquisition of cocaine self-administration under fixed-ratio (FR) schedules of...
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Relapse after intermittent access to cocaine: Discriminative cues more effectively trigger drug seeking than do conditioned cues
RationaleWhen people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include...
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The mGlu5 receptor negative allosteric modulator mavoglurant reduces escalated cocaine self-administration in male and female rats
RationaleCocaine use disorder (CUD) is a brain disorder for which there is no Food and Drug Administration-approved pharmacological treatment....
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Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk
BackgroundIndividuals with schizophrenia have high rates of comorbid substance use problems. One potential explanation for this comorbidity is...
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Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving
RationaleIncubation of cocaine craving refers to the progressive intensification of cue-induced craving during abstinence from cocaine...
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Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
BackgroundThe development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type...
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Oleoylethanolamide attenuates cocaine-primed reinstatement and alters dopaminergic gene expression in the striatum
The lipid oleoylethanolamide (OEA) has been shown to affect reward-related behavior. However, there is limited experimental evidence about the...
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D-amphetamine maintenance therapy reduces cocaine use in female rats
RationaleD-amphetamine maintenance therapy is a promising strategy to reduce drug use in cocaine use disorder (addiction). In both male rats and...
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Additive cortical gray matter deficits in people living with HIV who use cocaine
Cocaine use, which is disproportionately common in people living with HIV (PWH), is known to have neurotoxic effects that may exacerbate HIV...
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A Longitudinal Investigation of Blood Neurofilament Light Chain Levels in Chronic Cocaine Users
The identification of a blood marker of brain pathology that is sensitive to substance-induced neurotoxicity and dynamically responds to longitudinal...
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Cortico-striatal networking deficits associated with advanced HIV disease and cocaine use
Cocaine use is disproportionately prevalent in people with HIV (PWH) and is known to potentiate HIV neuropathogenesis. As both HIV and cocaine have...
