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Common Clinical Trial Designs
Clinical Trials are studies conducted for the purpose of assessing the effect of an intervention in a defined population, or to evaluate one or more...
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Elements of Clinical Trial Protocol Design
Clinical trials are conducted for many reasons, including to determine whether a new drug is safe and effective for a therapeutic use. A clinical...
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Neuropathological Assessment as an Endpoint in Clinical Trial Design
Different neurodegenerative conditions can have complex, overlapping clinical presentations that make accurate diagnosis during life very...
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Considerations and Advances in Huntington’s Disease Clinical Trial Design
The characterization of the Huntingtin gene in 1993, 10 years after it was the first disease-associated gene to be mapped to a chromosome in humans,...
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Clinical Trial with Synbiotics in Various Disease State
Simultaneous use of prebiotics and probiotics for human health benefit is generally called synbiotic. Prebiotics is nonviable nutritional food...
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Climate change advocacy and cancer clinical trial organisations
BackgroundClimate change is a threat to human health; equally health care is a threat to climate change as it accounts for 4% of greenhouse gas...
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The INGENIOUS trial: Impact of pharmacogenetic testing on adverse events in a pragmatic clinical trial
Adverse drug events (ADEs) account for a significant mortality, morbidity, and cost burden. Pharmacogenetic testing has the potential to reduce ADEs...
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Experiences of and recommendations on clinical trial design in Alzheimer’s disease from the participant’s point of view: a mixed-methods study in two clinical trial centers in the Netherlands
IntroductionIn the context of the development of pharmaceutical interventions, expectations and experiences of participants are essential. Their...
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Institutional barriers to clinical trial exploration experienced by the Latinx community
This study evaluated two types of barriers that the authors deemed important to resolve during the early stage of cancer clinical trial exploration...
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Interpersonal Values of Patients Participating in Phase II–III Clinical Trials: Implications for Clinical Trial Representativeness
BackgroundAn individual’s personal values strongly influence their immediate and long-term decisions. Psychological heterogeneity in clinical trial...
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NeuroEPO plus (NeuralCIM®) in mild-to-moderate Alzheimer’s clinical syndrome: the ATHENEA randomized clinical trial
BackgroundNeuroEPO plus is a recombinant human erythropoietin without erythropoietic activity and shorter plasma half-life due to its low sialic acid...
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A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients
BackgroundThis study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized...
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Novel Clinical Trial Designs in Neuro-Oncology
Scientific and technologic advances have led to a boon of candidate therapeutics for patients with malignancies of the central nervous system. The...
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AI-enabled electrocardiography alert intervention and all-cause mortality: a pragmatic randomized clinical trial
The early identification of vulnerable patients has the potential to improve outcomes but poses a substantial challenge in clinical practice. This...
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Impact of Clinical Trial Design on Recruitment of Racial and Ethnic Minorities
Knowledge related to how oncology treatment trial design influences enrollment of racial and ethnic minorities is limited. Rigorous identification of...
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Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity
BackgroundFecal microbiota transplantation (FMT) is a therapeutic intervention used to treat diseases associated with the gut microbiome. In the...
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Phase II clinical trial of sequential treatment with systemic chemotherapy and intraperitoneal paclitaxel for gastric and gastroesophageal junction peritoneal carcinomatosis - STOPGAP trial
BackgroundStudies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric...
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Diagnostic accuracy and clinical value of [68Ga]Ga-FAPI-46 PET/CT for staging patients with ovarian cancer: study protocol for a prospective clinical trial
Background[ 18 F]Fluorodeoxyglucose ([ 18 F]FDG) positron emission tomography (PET) is recommended during diagnostic work-up for ovarian cancer;...
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The current status of clinical trials on cancer and age disparities among the most common cancer trial participants
ObjectiveTo illustrate the status of all cancer clinical trials and characterize clinical trial enrollment disparities in the most common cancer.
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Evaluation of an artificial intelligence-based clinical trial matching system in Chinese patients with hepatocellular carcinoma: a retrospective study
BackgroundArtificial intelligence (AI)-assisted clinical trial screening is a promising prospect, although previous matching systems were developed...
