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Host sex disparity and viral genotype dependence of the glycosylation level of small Hepatitis B surface protein in patients with HBeAg-positive chronic Hepatitis B
BackgroundHepatitis B surface antigen (HBsAg) consists of six components of large/middle/small HBs proteins (L/M/SHBs) with non-glycosylated (ng)- or...
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Path to Cure Hepatitis B: How Far Are We?
Hepatitis B infection is caused by the hepatitis B virus (HBV), which damages the liver and can lead to chronic liver diseases such as cirrhosis and...
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Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
BackgroundIbrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of...
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Shared genetic factors and causal association between chronic hepatitis C infection and diffuse large B cell lymphoma
BackgroundEpidemiological research and systematic meta-analyses indicate a higher risk of B-cell lymphomas in patients with chronic hepatitis C virus...
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The Influence of ESR2 Gene Polymorphisms on Susceptibility to Hepatitis B Virus-Related Chronic Hepatitis, Liver Cirrhosis, and Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) represents an estrogen-dependent tumor. The action of estrogen is regulated via estrogen receptor (ER). Polymorphisms...
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Mutations in the S gene of hepatitis B virus in three generations of patients with chronic hepatitis B
Failure to neutralize HBsAg and subsequent escape from the host immune system may be caused by HBsAg mutations, particularly in the "a" determinant,...
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SOCS1 methylation level is associated with prognosis in patients with acute-on-chronic hepatitis B liver failure
BackgroundGlucocorticoids could greatly improve the prognosis of patients with acute-on-chronic hepatitis B liver failure (ACHBLF). Suppressor of...
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Creatine kinase elevation in chronic hepatitis B patients with telbivudine therapy: influence of telbivudine plasma concentration and single nucleotide polymorphisms of TK2, RRM2B, and NME4
PurposeTo study the correlations of genetic variants of telbivudine phosphorylase kinases and telbivudine plasma concentration with creatine kinase...
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Causal associations between chronic hepatitis B and COVID-19 in East Asian populations
BackgroundThe relationship between chronic hepatitis B (CHB) and Coronavirus disease 2019 (COVID-19) has been inconsistent in traditional...
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HCC prediction models in chronic hepatitis B patients receiving entecavir or tenofovir: a systematic review and meta-analysis
BackgroundOur study aimed to compare the predictive performance of different hepatocellular carcinoma (HCC) prediction models in chronic hepatitis B...
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Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways
BackgroundImmunotargets including checkpoint inhibitors and toll-like receptor 8 agonists have recently gained attention for the recovery of...
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Nanoscale Vaccines for the Prevention of Hepatitis B Virus Infection
Hepatitis B is a global life-threatening viral infection associated with a high risk of death resulting from chronic liver cirrhosis and liver...
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Cholesterol accumulation on dendritic cells reverses chronic hepatitis B virus infection-induced dysfunction
Chronic hepatitis B (CHB) infection remains a serious public health problem worldwide; however, the relationship between cholesterol levels and CHB...
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Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B
BackgroundHepatitis B virus (HBV) infection is a public health problem that seriously threatens human health. This study aimed to investigate the...
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Lower HBV DNA level is associated with more severe liver fibrosis in HBeAg-positive chronic hepatitis B with normal alanine transaminase
BackgroundThe association of hepatitis B virus (HBV) DNA levels and liver fibrosis in chronic hepatitis B (CHB) patients with immune-tolerant phase...
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Serum hepatitis B virus RNA detectability, composition and clinical significance in patients with ab initio hepatitis B e antigen negative chronic hepatitis B
BackgroundSerum hepatitis B virus (HBV) RNA is a surrogate biomarker for intrahepatic covalently closed circular DNA (cccDNA) transcriptional...
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Routine evaluation of HBV-specific T cell reactivity in chronic hepatitis B using a broad-spectrum T-cell epitope peptide library and ELISpot assay
BackgroundThe clinical routine test of HBV-specific T cell reactivity is still limited due to the high polymorphisms of human leukocyte antigens...
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Correlation analysis of hepatic steatosis and hepatitis B virus: a cross-sectional study
BackgroundThe co-occurrence of chronic hepatitis B (CHB) and metabolic dysfunction-associated fatty liver disease (MAFLD) has drawn considerable...
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A noninvasive model discriminating significant histological changes in treatment-naive chronic hepatitis B patients with normal ALT
BackgroundTraditionally part of chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) are recommended to antiviral therapy...
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Hepatitis Viruses
Hepatitis is a clinical syndrome caused by many pathogens, including viruses. Viral hepatitis denotes a primary infection caused by a heterologous...
