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CNS Drug Development and Delivery Concepts and Applications
The book covers recent advances in the field of CNS therapeutics, including opportunities posed by expanding basic knowledge related to CNS...
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BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion
Methylation class “CNS tumor with BCOR/BCOR(L1)-fusion” was recently defined based on methylation profiling and tSNE analysis of a series of 21...
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Gene therapy for CNS disorders: modalities, delivery and translational challenges
Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of...
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LXR agonism for CNS diseases: promises and challenges
The unfavorable prognosis of many neurological conditions could be attributed to limited tissue regeneration in central nervous system (CNS) and...
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The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Central nervous system (CNS)-resident cells such as microglia, oligodendrocytes and astrocytes are gaining increasing attention in respect to their...
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Underlying Mechanism of Lysosomal Membrane Permeabilization in CNS Injury: A Literature Review
Lysosomes play a crucial role in various intracellular pathways as their final destination. Various stressors, whether mild or severe, can induce...
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Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS
The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and whose composition changes as a function of an animal’s...
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PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans
Morphine and morphine-6-glucuronide (M6G) produce central nervous system (CNS) effects by activating mu-opioid receptors, while naloxone is used...
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Metabolic response to CNS infection with flaviviruses
Flaviviruses are arthropod-borne RNA viruses found worldwide that, when introduced into the human body, cause diseases, including neuroinfections,...
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CNS tumor stroma transcriptomics identify perivascular fibroblasts as predictors of immunotherapy resistance in glioblastoma patients
Excessive deposition of extracellular matrix (ECM) is a hallmark of solid tumors; however, it remains poorly understood which cellular and molecular...
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Impact of NQO1 dysregulation in CNS disorders
NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to...
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The Effect of Prenatal Stress on the Levels of Nitric Oxide Metabolites in the CNS
Abstract —Nitric oxide has several important functions in the CNS. This neurotransmitter regulates apoptotic processes, differentiation and...
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Contribution of CNS and extra-CNS infections to neurodegeneration: a narrative review
Central nervous system infections have been suggested as a possible cause for neurodegenerative diseases, particularly sporadic cases. They trigger...
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Spectrum of various CNS inflammatory demyelination diseases following COVID-19 vaccinations
Background and purposeAlthough rare, neurological adverse events have been reported post-COVID-19 vaccination. This study reports 16 patients...
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Olfactory immunology: the missing piece in airway and CNS defence
The olfactory mucosa is a component of the nasal airway that mediates the sense of smell. Recent studies point to an important role for the olfactory...
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Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Central nervous system (CNS) embryonal tumors are a heterogeneous group of high-grade malignancies, and the increasing clinical use of methylation...
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Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS
BackgroundMicroglia, an immune cell found exclusively within the CNS, initially develop from haematopoietic stem cell precursors in the yolk sac and...
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The Role of Microglial Depletion Approaches in Pathological Condition of CNS
Microglia are the primary immune cells of the central nervous system (CNS) that comprise about 5–12% of all cells in the brain. These cells are the...
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Targeting Non-Coding RNA for CNS Injuries: Regulation of Blood-Brain Barrier Functions
Central nervous system (CNS) injuries are the most common cause of death and disability around the world. The blood-brain barrier (BBB) is located at...
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The Gut Microbiome and the Central Nervous System (CNS)
The presence of resident microbial species in the human gastrointestinal tract has been known for a long time. However, only recently have they been...
