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The Complexity of Being A20: From Biological Functions to Genetic Associations
A20, encoded by TNFAIP3 , is a critical negative regulator of immune activation. A20 is a ubiquitin editing enzyme with multiple domains, each of...
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Influence of target location, task complexity, and gender on children’s use of their preferred foot
The goal of the present study was to compare the choice of foot of right-footed children with varying strengths of foot preference when performing...
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Schizophrenia genomics: genetic complexity and functional insights
Determining the causes of schizophrenia has been a notoriously intractable problem, resistant to a multitude of investigative approaches over...
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Diversity and complexity of cell death: a historical review
Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an...
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Phase separation of low-complexity domains in cellular function and disease
In this review, we discuss the ways in which recent studies of low-complexity (LC) domains have challenged our understanding of the mechanisms...
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Effect of low versus high balance training complexity on balance performance in male adolescents
ObjectiveThe current study aimed to determine the effects of low (i.e., balance task only) versus high (i.e., balance task combined with an...
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Sex differences of signal complexity at resting-state functional magnetic resonance imaging and their associations with the estrogen-signaling pathway in the brain
Sex differences in the brain have been widely reported and may hold the key to elucidating sex differences in many medical conditions and drug...
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From germ-free to wild: modulating microbiome complexity to understand mucosal immunology
The gut microbiota influences host responses at practically every level, and as research into host-microbe interactions expands, it is not surprising...
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Effects of emotional congruency and task complexity on decision-making
The heuristic approach to decision-making holds that the selection process becomes more efficient when part of the information available is ignored....
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Dissecting the complexity of local and systemic circadian communication in plants
The plant circadian clock regulates daily and seasonal rhythms of key biological processes, from growth and development to metabolism and physiology....
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Overcoming genetic and cellular complexity to study the pathophysiology of X-linked intellectual disabilities
X-linked genetic causes of intellectual disability (ID) account for a substantial proportion of cases and remain poorly understood, in part due to...
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Basic Properties of Biological Neurons and Synapses
In this chapter we shall make the case that in the study of brain function – from computational or clinical points of view – it is essential to take...
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Dynamic ctDNA Mutational Complexity in Patients with Melanoma Receiving Immunotherapy
BackgroundCirculating tumour DNA (ctDNA) analysis promises to improve the clinical care of people with cancer, address health inequities and guide...
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Bioanalytical Methods and Strategic Perspectives Addressing the Rising Complexity of Novel Bioconjugates and Delivery Routes for Biotherapeutics
In recent years, an increase in the discovery and development of biotherapeutics employing new modalities, such as bioconjugates or novel routes of...
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Limits to Information Transfer Through Biological Autoluminescence
A considerable body of experimental research suggests that cells communicate using weak optical signals. While the communication between biological...
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Reduced cortical complexity in patients with thyroid-associated ophthalmopathy
Psychical and functional disturbances of thyroid-associated ophthalmopathy (TAO) patients are drawing increasingly attention, despite the...
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Nanomaterials: Compatibility Towards Biological Interactions
With the expansion of nanotechnology, health care sector has seen a boom in the field of diagnostics and therapeutics. Despite heaps of research,...
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Association between life’s essential 8 and biological ageing among US adults
BackgroundBiological ageing is tightly linked to cardiovascular disease (CVD). We aimed to investigate the relationship between Life’s Essential 8...
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Biological and functional multimorbidity—from mechanisms to management
Globally, the number of people with multiple co-occurring diseases will increase substantially over the coming decades, with important consequences...
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Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-related diseases and increase healthspan have...
