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Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats
BackgroundSoluble amyloid-beta oligomers (Aβo) begin to accumulate in the human brain one to two decades before a clinical diagnosis of Alzheimer’s...
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Stabilization and Reduced Cytotoxicity of Amyloid Beta Aggregates in the Presence of Catechol Neurotransmitters
Oligomeric aggregates of the amyloid-beta (Aβ) peptide have been implicated as the toxic species for Alzheimer’s disease by contributing to oxidative...
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Role of Amyloid Beta in Neurodegeneration and Therapeutic Strategies for Neuroprotection
The gradual loss of neurons’ structure and function in the central nervous system is known as neurodegeneration. It is a defining feature of several...
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Amyloid Beta–Mediated Neurovascular Toxicity in Alzheimer’s Disease
The brain vascular system receives one-fifth of the total oxygen from the cardiac output, and this transport system is highly dependent on...
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Step by Step Toward an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease
Following the Alzheimer’s research decisive year 1987, the compass was set toward further exploration of the Amyloid–Alzheimer’s link. A great amount...
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The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature review
The extracellular buildup of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer’s disease (AD). Detection of Aβ pathology is essential...
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Evaluating the inter-species transmission risk of amyloid beta peptide aggregates via ingestion
BackgroundRecent reports suggest that amyloid beta (Aβ) peptides can exhibit prion-like pathogenic properties. Transmission of Aβ peptide and the...
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Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation
AbstractAlzheimer’s disease (AD) is characterized by intracerebral deposition of abnormal proteinaceous assemblies made of amyloid-β (Aß) peptides or...
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Rose Bengal inhibits β-amyloid oligomers-induced tau hyperphosphorylation via acting on Akt and CDK5 kinases
RationaleTau hyperphosphorylation and aggregation is considered as a main pathological mechanism underlying Alzheimer’s disease (AD). Rose Bengal...
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Systematic review and meta-analysis of randomized controlled trials on the effects of exercise interventions on amyloid beta levels in humans
Alzheimer’s disease (AD) represents the most common type of dementia. A crucial mechanism attributed to its development is amyloid beta (Aβ) dynamics...
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Lecanemab, Aducanumab, and Gantenerumab — Binding Profiles to Different Forms of Amyloid-Beta Might Explain Efficacy and Side Effects in Clinical Trials for Alzheimer’s Disease
Immunotherapy against amyloid-beta (Aβ) is a promising option for the treatment of Alzheimer’s disease (AD). Aβ exists as various species, including...
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The Amyloid Cascade Hypothesis Has to Deliver, Finally
The Alzheimer’s field has been intensively searching for a therapy, especially in the last 30 years, while the number of affected individuals has...
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Cellulose ether treatment inhibits amyloid beta aggregation, neuroinflammation and cognitive deficits in transgenic mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is an incurable, progressive and devastating neurodegenerative disease. Pathogenesis of AD is associated with the...
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Proteomics revealed an association between ribosome-associated proteins and amyloid beta deposition in Alzheimer's disease
Most scholars believe that amyloid-beta (Aβ) has the potential to induce apoptosis, stimulate an inflammatory cascade, promote oxidative stress and...
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Understanding the Mechanisms of Amyloid Beta (Aβ) Aggregation by Computational Modeling
The misfolding, aggregation, and formation of complex self-assemblies of amyloid-beta (Aβ) are the key events in the pathophysiology of Alzheimer’s...
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Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease
BackgroundAlzheimer's disease (AD) is the most prevalent neurodegenerative disorder. Impaired autophagy in plaque-associated microglia (PAM) has been...
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A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice
Amyloid-β (Aβ) oligomers and protofibrils are suggested to be the most neurotoxic Aβ species in Alzheimer’s disease (AD). Hence, antibodies with...
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Plasma amyloid-beta oligomer is related to subjective cognitive decline and brain amyloid status
BackgroundSubjective cognitive decline (SCD) is a target for Alzheimer’s disease prediction. Plasma amyloid-beta oligomer (AβO), the pathogenic form...
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Current Insights of Nanocarrier-Mediated Gene Therapeutics to Treat Potential Impairment of Amyloid Beta Protein and Tau Protein in Alzheimer’s Disease
Alzheimer’s disease (AD), is the major type of dementia and most progressive, irreversible widespread neurodegenerative disorder affecting the...
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Avicularin Attenuates Memory Impairment in Rats with Amyloid Beta-Induced Alzheimer’s Disease
Amyloid-beta-induced Alzheimer’s disease (AD) and its further complications are well-established models in preclinical studies and demonstrated by...
