Search
Search Results
-
B-Cell Development, Maturation, and Activation
B cells originate from hematopoietic stem cells in the bone marrow, which is the site of B-cell development and maturation (bursa of Fabricius in...
-
Endothelial-derived small extracellular vesicles support B-cell acute lymphoblastic leukemia development
PurposeThe bone marrow niche plays an important role in leukemia development. However, the contributions of different niche components to leukemia...
-
MECOM Deficiency: from Bone Marrow Failure to Impaired B-Cell Development
MECOM deficiency is a recently identified inborn error of immunity and inherited bone marrow failure syndrome caused by haploinsufficiency of the...
-
Eukaryotic initiation factor 3a promotes the development of diffuse large B-cell lymphoma through regulating cell proliferation
BackgroundOne-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a...
-
The Autoimmune Manifestations in Patients with Genetic Defects in the B Cell Development and Differentiation Stages
PurposePrimary B cell defects manifesting as predominantly antibody deficiencies result from variable inborn errors of the B cell lineage and their...
-
Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation
The nuclear corepressors NCOR1 and NCOR2 interact with transcription factors involved in B cell development and potentially link these factors to...
-
Unraveling the role of hepatitis B virus DNA integration in B-cell lymphomagenesis
BackgroundStudies have shown that hepatitis B virus (HBV)-associated B-cell non-Hodgkin lymphoma (NHL) constitutes a unique subgroup with distinct...
-
The Expression of Non B Cell-Derived Immunoglobulins
Although V(D)J recombination and immunoglobulin (Ig) production are traditionally recognised to occur only in B lymphocytes and plasma cells, the...
-
IL-12 induces a B cell-intrinsic IL-12/IFNγ feed-forward loop promoting extrafollicular B cell responses
While some infections elicit germinal centers, others produce only extrafollicular responses. The mechanisms controlling these dichotomous fates are...
-
Development of EBV Related Diffuse Large B-cell Lymphoma in Deficiency of Adenosine Deaminase 2 with Uncontrolled EBV Infection
Deficiency of Adenosine Deaminase 2 (DADA2) patients presenting with primary immunodeficiency are at risk of uncontrolled EBV infection and secondary...
-
The Gene Rearrangement and Transcriptional Regulation of Non B Cell-Derived Immunoglobulin
Traditionally, immunoglobulin (Ig) expression has been attributed solely to B cells/plasma cells with well-documented and accepted regulatory...
-
Tracking Circulating HLA-Specific IgG-Producing Memory B Cells with the B-Cell ImmunoSpot Assay
Donor-specific antibodies (DSA) against human leukocyte antigen (HLA) molecules are a major risk factor for rejection of transplanted organs (in...
-
The Structure Characteristics and Function of Non B Cell-Derived Immunoglobulin
According to classical immunology theory, immunoglobulin (Ig) is exclusively produced by differentiated B lymphocytes, which exhibit a typical...
-
Conserved stromal–immune cell circuits secure B cell homeostasis and function
B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance...
-
Non B Cell-Derived Immunoglobulins in Intestinal Tract
Intestinal epithelium constitutes a barrier to the unrestricted movement of pathogens, and other detrimental substances from the external world (gut...
-
B-Cell Epitope Predictions Using Computational Methods
Identifying protein antigenic epitopes that are recognizable by antibodies is a key step in immunologic research. This type of research has broad...
-
Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy
Myasthenia gravis (MG) is an autoantibody-mediated autoimmune disorder of the neuromuscular junction. A small subset of patients (<10%) with MG, have...
-
Genomic, transcriptomic and epigenomic sequencing data of the B-cell leukemia cell line REH
ObjectivesThe aim of this data paper is to describe a collection of 33 genomic, transcriptomic and epigenomic sequencing datasets of the B-cell acute...
-
Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases
The screening of antigen-specific B cells has been pivotal for biotherapeutic development for over four decades. Conventional antibody discovery...
-
PICH deficiency limits the progression of MYC-induced B-cell lymphoma
Plk1-interacting checkpoint helicase (PICH) is a DNA translocase involved in resolving ultrafine anaphase DNA bridges and, therefore, is important to...
