Search
Search Results
-
Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes
Upregulation of diverse self-antigens that constitute components of the inflammatory response overlaps spatially and temporally with the emergence of...
-
Evaluation of Autoreactive Responses
Loss of tolerance to self-antigens is considered to be one of the initial reasons for the onset of rheumatoid arthritis (RA). Identification of...
-
How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion
Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to...
-
IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE
Interleukin-17A plays a crucial role in multiple sclerosis and other autoimmune diseases. Although the link between IL-17 and disease activity has...
-
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3
Impaired chronic viral and tumor clearance has been attributed to CD8 + T cell exhaustion, a differentiation state in which T cells have reduced and...
-
-
Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies has been...
-
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3
Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4 + T cells expressing a...
-
Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into a systemic immunological...
-
Double-edged sword: γδ T cells in mucosal homeostasis and disease
The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in...
-
Release of Antibodies and Cytokines from B Cells
Autoreactive B cells play a critical role in rheumatoid arthritis (RA). These cells differentiate into long-living memory B cells and...
-
GPR43 stimulation on TCRαβ+ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity
IntroductionGut microbiota plays a critical role in the regulation of immune homeostasis. Accordingly, several autoimmune disorders have been...
-
Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a
Expressed on epidermal Langerhans cells, CD1a presents a range of self-lipid antigens found within the skin; however, the extent to which CD1a...
-
Concise review: The heterogenous roles of BATF3 in cancer oncogenesis and dendritic cells and T cells differentiation and function considering the importance of BATF3-dependent dendritic cells
The transcription factor, known as basic leucine zipper ATF-like 3 (BATF3), is a crucial contributor to the development of conventional type 1...
-
The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review
BackgroundRegulatory T cells (Tregs) play vital roles in controlling immune reactions and maintaining immune tolerance in the body. The targeted...
-
Metabolic regulation and function of T helper cells in neuroinflammation
Neuroinflammatory conditions such as multiple sclerosis (MS) are initiated by pathogenic immune cells invading the central nervous system (CNS)....
-
A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model
Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we lack a comprehensive understanding of the signaling...
-
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity
Regulatory T cells (T reg cells) are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which T reg ...
-
FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors
BackgroundPrevious research in FMS-like tyrosine kinase 3 ligands (FLT3L) has primarily focused on their potential to generate dendritic cells (DCs)...
-
Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles
While the functions of αβ T cells in host resistance to pathogen infection are understood in far more detail than those of γδ lineage T cells, γδ T...
