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Sex-dependent effects of acute stress in adolescence or adulthood on appetitive motivation
RationaleIntensely stressful experiences can lead to long-lasting changes in appetitive and aversive behaviors. In humans, post-traumatic stress...
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Corticosterone after early adolescent stress prevents social avoidance, aversive behavior, and morphine-conditioned place preference in adulthood
RationaleStress during childhood or adolescence increases vulnerability to psychiatric disorders in adults. In adult rodents, the delayed effects of...
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Myhre syndrome in adulthood: clinical variability and emerging genotype-phenotype correlations
Myhre syndrome (MS, MIM 139210) is a rare multisystemic disorder caused by recurrent pathogenic missense variants in SMAD4 . The clinical features...
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Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer
BackgroundBody fatness is a dynamic exposure throughout life. To provide more insight into the association between body mass index (BMI) and...
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Weigh change across adulthood is related to the presence of NAFLD: results from NHANES III
BackgroundObesity is a widely recognized driving factor of Non-alcoholic fatty liver disease (NAFLD), it remains unclear whether historical weight...
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Fetal Alcohol Spectrum Disorder: Challenges in Adulthood
Although frequently viewed as a childhood disorder, FASD is a lifelong condition with implications for function and well-being across the lifespan....
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Superficial white matter across development, young adulthood, and aging: volume, thickness, and relationship with cortical features
Superficial white matter (SWM) represents a significantly understudied part of the human brain, despite comprising a large portion of brain volume...
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Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood
BackgroundEarly-life adversities during development (e.g., child abuse and neglect) are linked to multiple behavioral and cognitive dysfunctions,...
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The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates
Nicotine and tobacco product (NTP) use remains prevalent in adolescence/young adulthood. The effects of NTPs on markers of brain health during this...
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Trust in adolescence and depression and anxiety symptoms in young adulthood: findings from a Swedish cohort
ObjectiveTrust and health are both fundamental elements of a socially sustainable society. While much research has shown that trust is associated...
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Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood
Despite growing concern about adverse effects of bisphenol AF (BPAF) due to its endocrine disrupting properties, there is a lack of toxicity data...
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Neonatal Isoflurane Exposure in Rats Impairs Short-Term Memory, Cell Viability, and Glutamate Uptake in Slices of the Frontal Cerebral Cortex, But Not the Hippocampus, in Adulthood
Neonatal exposure to general anesthetics has been associated with neurotoxicity and morphologic changes in the developing brain. Isoflurane is a...
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Associations between the use of insecticide-treated nets in early childhood and educational outcomes, marriage and child-bearing in early adulthood: evidence from a 22-year prospective cohort study in Tanzania
BackgroundThe effectiveness of insecticide-treated nets (ITNs) in preventing malaria in young children is well established. However, the long-term...
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Long-Lasting Impact of Sugar Intake on Neurotrophins and Neurotransmitters from Adolescence to Young Adulthood in Rat Frontal Cortex
The detrimental impact of fructose, a widely used sweetener in industrial foods, was previously evidenced on various brain regions. Although...
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Pre-weaning fluoxetine exposure caused anti-depressant like behavior at adulthood via perturbing tryptophan metabolism in rats
The perinatal depression exposes the child to antidepressants during vulnerable window of development, which can chronically impact the mental...
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Cognitive performance during adulthood in a rat model of neonatal diffuse white matter injury
RationaleInfants born prematurely risk developing diffuse white matter injury (WMI), which is associated with impaired cognitive functioning and an...
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Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood
Stress exposure during early stages of life elevates the risk of developing psychopathologies and psychiatric illness in later life. The brain and...
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Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood
A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories...
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DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
BackgroundPuberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early...
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