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L-carnitine and Acetyl-L Carnitine: A Possibility for Treating Alterations Induced by Obesity in the Central Nervous System
Excessive consumption of nutrients, as well as obesity, leads to an inflammatory process, especially in adipose tissue. This inflammation reaches the...
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The Effect of Acetyl-L-Carnitine (ALCAR) on Peripheral Nerve Regeneration in Animal Models: A Systematic Review
Peripheral neuropathies caused by the peripheral nervous system (PNS) damage can occur due to trauma and other disorders. They present as altered...
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Acetyl-L-Carnitine Exerts Neuroprotective and Anticonvulsant Effect in Kainate Murine Model of Temporal Lobe Epilepsy
The most well-known type of focal epilepsy that is resistant to existing treatments is temporal lobe epilepsy (TLE), with seizure foci in various...
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Acetyl-L-carnitine confers neuroprotection against lipopolysaccharide (LPS) -induced neuroinflammation by targeting TLR4/NFκB, autophagy, inflammation and oxidative stress
Acetyl-L-carnitine has been shown to exert neuroprotection against neurodegenerative diseases. The present study was performed to evaluate...
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Use of Acetyl-L-Carnitine in Gerontological Practice
Published data on the efficacy and safety of using acetyl-L-carnitine (ALC) in gerontological practice are analyzed and the spectrum of biochemical...
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Correction to: Acetyl-L-carnitine confers neuroprotection against lipopolysaccharide (LPS) -induced neuroinflammation by targeting TLR4/NFκB, autophagy, inflammation and oxidative stress
A Correction to this paper has been published: 10.1007/s11011-021-00721-8
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Antioxidant supplementation may effect DNA methylation patterns, apoptosis, and ROS levels in developing mouse embryos
This study was designed to address the question: does antioxidant-containing embryo culture media affect DNA methyltransferases, global DNA...
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Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
BackgroundProstate cancer (PCa) is a leading cause of cancer-related death in males worldwide. Exacerbated inflammation and angiogenesis have been...
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Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
BackgroundAlzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently...
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Effect of Acetyl-l-carnitine Used for Protection of Neonatal Hypoxic-Ischemic Brain Injury on Acute Kidney Changes in Male and Female Rats
Neonatal hypoxia-ischemia (HI) is a common cause of brain injury in infants. Acute kidney injury frequently occurs after birth asphyxia and is...
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Mechanistic perspectives on differential mitochondrial-based neuroprotective effects of several carnitine forms in Alzheimer’s disease in vitro model
Mitochondrial deregulation has emerged as one of the earliest pathological events in Alzheimer’s disease (AD), the most common age-related...
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Screening Methods for the Evaluation of Hepatoprotective Agents
Liver being the major site of metabolism of xenobiotics, it is predisposed to the harmful effects of the toxic metabolites generated during...
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Pharmacological Treatment of Established Chemotherapy-Induced Peripheral Neuropathy
Pharmacological treatment of chemotherapy-induced peripheral neuropathy (CIPN) is still in its infancy and available options are limited. Both...
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BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria
BackgroundPancreatic ductal adenocarcinoma (PDAC) has been associated with the host dysmetabolism of branched-chain amino acids (BCAAs), however, the...
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Screening of melatonin, α-tocopherol, folic acid, acetyl-l-carnitine and resveratrol for anti-dengue 2 virus activity
ObjectiveInfections with the mosquito transmitted dengue virus (DENV) are a significant public health burden in many parts of the world. Despite the...
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Metabolic Approaches to the Treatment of Autism Spectrum Disorders
Children with autism spectrum disorder (ASD) may exhibit metabolic abnormalities, either with or without an underlying inherited metabolic...
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Fluoride impairs vascular smooth muscle A7R5 cell lines via disrupting amino acids metabolism
Given the insidious and high-fatality nature of cardiovascular diseases (CVDs), the emergence of fluoride as a newly identified risk factor demands...
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Anomalies of Energy Metabolism in Schizophrenia and Possible Pathogenetically Targeted Therapeutic Approaches
Abstract —Coordinated regulation of energy conversion processes in the brain maintains its highly productive work and efficient mental activity....
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Clinical Application and Trials with Nutraceuticals
Pharmaceutical drugs are chemical compounds that are designed to prevent, diagnose, and treat a specific disorder. Nutraceuticals are products that...
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Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity
Myocardial regeneration capacity declines during the first week after birth, and this decline is linked to adaptation to oxidative metabolism....
