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Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core
BackgroundGlutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. Although behavioral...
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Molecular Profiling of VGluT1 AND VGluT2 Ventral Subiculum to Nucleus Accumbens Shell Projections
The nucleus accumbens shell is a critical node in reward circuitry, encoding environments associated with reward. Long-range inputs from the ventral...
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Visualization of the existence of growth hormone secretagogue receptor in the rat nucleus accumbens
The potential role of the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR), within the nucleus accumbens (NAcc) in...
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Serotonin and Dopamine Show Different Response Profiles to Acute Stress in the Nucleus Accumbens and Medial Prefrontal Cortex of Rats with Neuropathic Pain
The ability to adaptively guide behaviour requires the integration of external information with internal motivational factors. Decision-making...
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Sex differences in mouse infralimbic cortex projections to the nucleus accumbens shell
BackgroundThe nucleus accumbens (NAc) is an important region in motivation and reward. Glutamatergic inputs from the infralimbic cortex (ILC) to the...
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Anatomical analyses of collateral prefrontal cortex projections to the basolateral amygdala and the nucleus accumbens core in rats
The basolateral amygdala (BLA) and the nucleus accumbens core (NAcc) share some similar behavioral functions, such as associative learning, Pavlovian...
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Proteome profile of nucleus accumbens (NAc) uncovers the differential and sex-specific role of CRMP2 in CVMS-induced mouse model of depression
Chronic stress plays a very important role in building pathogenesis of psychiatric disorders including major depressive disorder (MDD). Despite of...
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Prokineticin-2 Participates in Chronic Constriction Injury-Triggered Neuropathic Pain and Anxiety via Regulated by NF-κB in Nucleus Accumbens Shell in Rats
Neuropathic pain (NP) is an intractable pain that results from primary nervous system injury and dysfunction. Herein, we demonstrated in animal...
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Nucleus accumbens ghrelin signaling controls anxiety-like behavioral response to acute stress
BackgroundAnxiety disorders are one of the most common mental disorders. Ghrelin is a critical orexigenic brain-gut peptide that regulates food...
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Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving
RationaleIncubation of cocaine craving refers to the progressive intensification of cue-induced craving during abstinence from cocaine...
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CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice
Methamphetamine (Meth), a commonly used central nervous system stimulant, is highly addictive. Currently, there is no effective treatment for Meth...
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Modulation of Nicotine-Associated Behaviour in Rats By μ-Opioid Signals from the Medial Prefrontal Cortex to the Nucleus Accumbens Shell
Nicotine addiction is a concern worldwide. Most mechanistic investigations are on nicotine substance dependence properties based on its...
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Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens
Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the...
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Dopamine signaling in the nucleus accumbens core mediates latent inhibition
Studies investigating the neural mechanisms by which associations between cues and predicted outcomes control behavior often use associative learning...
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Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults
RationaleStimulant drugs like methamphetamine (MA) activate brain reward circuitry, which is linked to the development of problematic drug use. It is...
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Sex differences in membrane properties and cellular excitability of dopamine D1 receptor-expressing neurons within the shell of the nucleus accumbens of pre- and mid-adolescent mice
BackgroundThe transition from childhood to adulthood, or adolescence, a developmental stage, is characterized by psychosocial and biological changes....
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Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
BackgroundThe development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type...
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GABAergic Neurons in the Nucleus Accumbens are Involved in the General Anesthesia Effect of Propofol
The mechanism underlying the hypnosis effect of propofol is still not fully understood. In essence, the nucleus accumbens (NAc) is crucial for...
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Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating
Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder...
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Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
